Seroatlas · Human Serome Atlas

TMEM217B

Transmembrane protein 217B

Also known as: T217B_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
A0A494BZU4
Gene
TMEM217B
Ensembl
ENSG00000286105
Chromosome
6
Canonical length
170 aa
Protein class
Predicted membrane proteins

OverviewNCBI Gene

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

170 residues, UniProt reviewed canonical sequence.

>A0A494BZU4|TMEM217B
     1  MNVRMFSLMV GIFSVLNTTQ FFIFDLNQKT HICYEAKFSI YVDSKSELVT WTLFHRANIS
    61  TGLSLTTIII GCFLFYCIHK NIYMGLLIYA MWIITYELIN FSIVLLLNGI IKDHFKTLSY
   121  LHWIFQISHM LLHFFCLPFI VKHAYNLYKE SQTVGRKRRH RLCSTIAVNS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TMEM217B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
3
Mean surface accessibility (rSASA)
0.35
Highest tissue expression
9.9 nTPM

Expression across tissuesHPA

Tissue

  • testis: 9.9 nTPM
  • adrenal gland: 1 nTPM
  • salivary gland: 1 nTPM
  • esophagus: 0.9 nTPM
  • bone marrow: 0.7 nTPM
  • lung: 0.6 nTPM

Single-cell type

  • adipocytes: 0 nCPM
  • adrenal cortex cells: 0 nCPM
  • adrenal medulla cells: 0 nCPM
  • alveolar cells type 1: 0 nCPM
  • alveolar cells type 2: 0 nCPM
  • b-cells: 0 nCPM

Immune cell

  • basophil: 0.4 nTPM
  • memory CD8 T-cell: 0.1 nTPM
  • plasmacytoid DC: 0.1 nTPM
  • T-reg: 0.1 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM

Brain region

  • thalamus: 0.5 nTPM
  • cerebral cortex: 0.4 nTPM
  • basal ganglia: 0.2 nTPM
  • hippocampal formation: 0.2 nTPM
  • hypothalamus: 0.2 nTPM
  • pons: 0.2 nTPM

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TMEM217B as an antibody target. Whether an autoantibody or antibody against TMEM217B could matter depends on whether native TMEM217B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TMEM217B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TMEM217B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TMEM217B. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...