Seroatlas · Human Serome Atlas

TMEM217

Transmembrane protein 217

Also known as: C6orf128, dJ355M6.2, TM217_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8N7C4
Gene: TMEM217
Ensembl: ENSG00000172738
Chromosome: 6
Canonical length: 229 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Nucleoli,Cytosol

OverviewNCBI Gene

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

229 residues, UniProt reviewed canonical sequence.

>Q8N7C4|TMEM217
     1  MKQQQWCGMT AKMGTVLSGV FTIMAVDMYL IFEQKHLGNG SCTEITPKYR GASNIINNFI
    61  ICWSFKIVLF LSFITILISC FLLYSVYAQI FRGLVIYIVW IFFYETANVV IQILTNNDFD
   121  IKEVRIMRWF GLVSRTVMHC FWMFFVINYA HITYKNRSQG NIISYKRRIS TAEILHSRNK
   181  RLSISSGFSG SHLESQYFER QSFHTSIFTC LSPVPSSAPS TCRYTIDVC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TMEM217 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 4
Mean surface accessibility (rSASA): 0.43
Highest tissue expression: 8.4 nTPM

Expression across tissuesHPA

Tissue

testis: 8.4 nTPM
adrenal gland: 3.6 nTPM
bone marrow: 2.6 nTPM
pancreas: 2.5 nTPM
salivary gland: 2.1 nTPM
urinary bladder: 2.1 nTPM

Single-cell type

proximal tubule cells: 8.8 nCPM
loop of henle epithelial cells: 7.8 nCPM
papillary tip epithelial cells: 6.9 nCPM
ependymal cells: 5.9 nCPM
renal connecting tubule cells: 5.6 nCPM
bergmann glia: 5.4 nCPM

Immune cell

naive B-cell: 0.2 nTPM
neutrophil: 0.2 nTPM
basophil: 0.1 nTPM
gdT-cell: 0.1 nTPM
memory CD4 T-cell: 0.1 nTPM
myeloid DC: 0.1 nTPM

Brain region

white matter: 1.6 nTPM
cerebellum: 1.5 nTPM
cerebral cortex: 1.5 nTPM
pons: 1.5 nTPM
basal ganglia: 1.4 nTPM
medulla oblongata: 1.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.5
gnomAD pLI: 0
gnomAD missense Z: 0.8
DepMap mean gene effect: -0.09
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TMEM217 as an antibody target. Whether an autoantibody or antibody against TMEM217 could matter depends on whether native TMEM217 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TMEM217 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TMEM217 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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