Seroatlas · Human Serome Atlas

TMEM215

Transmembrane protein 215

Also known as: TM215_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q68D42
Gene: TMEM215
Ensembl: ENSG00000188133
Chromosome: 9
Canonical length: 235 aa
Protein class: Predicted membrane proteins
Subcellular location: Nucleoplasm,Vesicles

OverviewNCBI Gene

Predicted to act upstream of or within negative regulation of retinal cell programmed cell death and sprouting angiogenesis. Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

235 residues, UniProt reviewed canonical sequence.

>Q68D42|TMEM215
     1  MRPDDINPRT GLVVALVSVF LVFGFMFTVS GMKGETLGNI PLLAIGPAIC LPGIAAIALA
    61  RKTEGCTKWP ENELLWVRKL PCFRKPKDKE VVELLRTPSD LESGKGSSDE LAKKAGLRGK
   121  PPPQSQGEVS VASSINSPTP TEEGECQSLV QNGHQEETSR YLDGYCPSGS SLTYSALDVK
   181  CSARDRSECP EPEDSIFFVP QDSIIVCSYK QNSPYDRYCC YINQIQGRWD HETIV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TMEM215 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 2
Mean surface accessibility (rSASA): 0.6
Highest tissue expression: 17 nTPM

Expression across tissuesHPA

Tissue

retina: 17 nTPM
testis: 2.5 nTPM
endometrium: 2.1 nTPM
ovary: 2.1 nTPM
thyroid gland: 0.8 nTPM
cervix: 0.6 nTPM

Single-cell type

late spermatids: 575 nCPM
retinal bipolar cells: 477 nCPM
early spermatids: 158 nCPM
retinal amacrine cells: 26 nCPM
late primary spermatocytes: 12 nCPM
brain inhibitory neurons: 6.4 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

hypothalamus: 14 nTPM
midbrain: 3.7 nTPM
amygdala: 2.8 nTPM
basal ganglia: 2.1 nTPM
thalamus: 1.7 nTPM
hippocampal formation: 1.6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.58
gnomAD pLI: 0
gnomAD missense Z: 0.82
DepMap mean gene effect: -0.01
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

membrane

Protein domainsUniProt · Pfam · InterPro

Transmembrane protein 215
TMEM215 family

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TMEM215 as an antibody target. Whether an autoantibody or antibody against TMEM215 could matter depends on whether native TMEM215 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TMEM215 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TMEM215 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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