Seroatlas · Human Serome Atlas

TMEM213

Transmembrane protein 213

Also known as: TM213_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
A2RRL7
Gene
TMEM213
Ensembl
ENSG00000214128
Chromosome
7
Canonical length
107 aa
Protein class
Predicted intracellular proteins, Predicted membrane proteins

OverviewNCBI Gene

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

107 residues, UniProt reviewed canonical sequence.

>A2RRL7|TMEM213
     1  MQRLPAATRA TLILSLAFAS LHSACSAEAS SSNSSSLTAH HPDPGTLEQC LNVDFCPQAA
    61  RCCRTGVDEY GWIAAAVGWS LWFLTLILLC VDKLMKLTPD EPKDLQA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TMEM213 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.58
Highest tissue expression
71 nTPM

Expression across tissuesHPA

Tissue

  • kidney: 71 nTPM
  • salivary gland: 49 nTPM
  • skin: 5 nTPM
  • breast: 4.4 nTPM
  • cervix: 2.6 nTPM
  • duodenum: 1.2 nTPM

Single-cell type

  • epididymal clear cells: 951 nCPM
  • renal collecting duct intercalated cells: 591 nCPM
  • salivary duct cells: 423 nCPM
  • distal convoluted tubule cells: 316 nCPM
  • conjunctival goblet cells: 238 nCPM
  • renal connecting tubule cells: 174 nCPM

Immune cell

  • basophil: 2.1 nTPM
  • NK-cell: 1.9 nTPM
  • neutrophil: 0.9 nTPM
  • MAIT T-cell: 0.4 nTPM
  • classical monocyte: 0.2 nTPM
  • eosinophil: 0.2 nTPM

Brain region

  • white matter: 5.3 nTPM
  • cerebral cortex: 4.9 nTPM
  • hippocampal formation: 4.8 nTPM
  • cerebellum: 4.7 nTPM
  • thalamus: 4.7 nTPM
  • amygdala: 4.6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.36
gnomAD pLI
0.09
gnomAD missense Z
0.24
DepMap mean gene effect
-0.02
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • TMEM213 family
  • TMEM213 family

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TMEM213 as an antibody target. Whether an autoantibody or antibody against TMEM213 could matter depends on whether native TMEM213 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TMEM213 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TMEM213 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TMEM213. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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