Seroatlas · Human Serome Atlas

TMEM212

Transmembrane protein 212

Also known as: FLJ23172, TM212_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
A6NML5
Gene
TMEM212
Ensembl
ENSG00000186329
Chromosome
3
Canonical length
194 aa
Protein class
Predicted membrane proteins, Transporters
Subcellular location
Nucleoli fibrillar center,Endoplasmic reticulum

OverviewNCBI Gene

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

194 residues, UniProt reviewed canonical sequence.

>A6NML5|TMEM212
     1  MKGLYQAAGR ILVTLGILSV CSGVIAFFPV FSYKPWFTGW SVRIACPIWN GALAITTGVL
    61  LLLAYREWTQ RYLGEATFTF VILSIMGCPL HFAIALESAL LGPYCFYSFS GIAGTNYLGY
   121  AVTFPYPYAK FPLACVDPPH YEEYHLTLQA LDLCLSFTLL CTSLTVFIKL SARLIQNGHI
   181  NMQLPAGNPN PFSP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TMEM212 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
5
Mean surface accessibility (rSASA)
0.32
Highest tissue expression
28 nTPM

Expression across tissuesHPA

Tissue

  • fallopian tube: 28 nTPM
  • retina: 6.8 nTPM
  • liver: 5.8 nTPM
  • lung: 3.9 nTPM
  • bone marrow: 3.2 nTPM
  • skeletal muscle: 2.4 nTPM

Single-cell type

  • respiratory ciliated cells: 255 nCPM
  • fallopian tube ciliated cells: 124 nCPM
  • endometrial ciliated cells: 26 nCPM
  • undifferentiated spermatogonia: 25 nCPM
  • epicardial cells: 23 nCPM
  • ependymal cells: 15 nCPM

Immune cell

  • basophil: 3 nTPM
  • neutrophil: 1.5 nTPM
  • NK-cell: 1.2 nTPM
  • naive B-cell: 1 nTPM
  • plasmacytoid DC: 1 nTPM
  • gdT-cell: 0.7 nTPM

Brain region

  • cerebellum: 102 nTPM
  • cerebral cortex: 96 nTPM
  • white matter: 91 nTPM
  • basal ganglia: 75 nTPM
  • midbrain: 75 nTPM
  • hippocampal formation: 74 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.8
gnomAD pLI
0
gnomAD missense Z
1.04
DepMap mean gene effect
0.06
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TMEM212 as an antibody target. Whether an autoantibody or antibody against TMEM212 could matter depends on whether native TMEM212 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TMEM212 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TMEM212 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TMEM212. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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