Seroatlas · Human Serome Atlas

TMEM210

Transmembrane protein 210

Also known as: TM210_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
A6NLX4
Gene
TMEM210
Ensembl
ENSG00000185863
Chromosome
9
Canonical length
147 aa
Protein class
Predicted membrane proteins

OverviewNCBI Gene

Located in acrosomal vesicle. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

147 residues, UniProt reviewed canonical sequence.

>A6NLX4|TMEM210
     1  MAPGPWPVSC LRGGPLGLTY LSLLLIPAAA GTYCECSLGL SREALIALLV VLAGISASCF
    61  CALVIVAIGV LRAKGETCPR QVDNRLVENF GVQEDLMDLH PVYVESQLMD ADLEVSLVPP
   121  LEDQSLVAIP MEASSEEPPP PPPLPPE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TMEM210 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.65
Highest tissue expression
33 nTPM

Expression across tissuesHPA

Tissue

  • testis: 33 nTPM
  • salivary gland: 1.4 nTPM
  • epididymis: 0.5 nTPM
  • breast: 0.3 nTPM
  • pancreas: 0.2 nTPM
  • prostate: 0.2 nTPM

Single-cell type

  • late spermatids: 2,539 nCPM
  • early spermatids: 957 nCPM
  • late primary spermatocytes: 233 nCPM
  • sertoli cells: 6.5 nCPM
  • peritubular myoid cells: 3 nCPM
  • pdcs: 2.5 nCPM

Immune cell

  • plasmacytoid DC: 3.3 nTPM
  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM

Brain region

  • cerebellum: 0.8 nTPM
  • basal ganglia: 0.5 nTPM
  • cerebral cortex: 0.5 nTPM
  • hippocampal formation: 0.4 nTPM
  • hypothalamus: 0.3 nTPM
  • white matter: 0.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.89
gnomAD pLI
0.64
gnomAD missense Z
0.21
DepMap mean gene effect
0.02
DepMap dependency class
selective

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • TMEM210 family
  • TMEM210 family

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TMEM210 as an antibody target. Whether an autoantibody or antibody against TMEM210 could matter depends on whether native TMEM210 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TMEM210 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TMEM210 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TMEM210. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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