Seroatlas · Human Serome Atlas

TMEM208

Transmembrane protein 208

Also known as: hSND2, HSPC171, TM208_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BTX3
Gene: TMEM208
Ensembl: ENSG00000168701
Chromosome: 16
Canonical length: 173 aa
Protein class: Predicted membrane proteins, Transporters

OverviewNCBI Gene

This gene encodes a highly conserved protein which is localized in the endoplasmic reticulum (ER). The protein is linked to autophagy and ER stress. Knockdown of this gene increased autophagy and triggered ER stress. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]

Canonical amino-acid sequenceUniProt

173 residues, UniProt reviewed canonical sequence.

>Q9BTX3|TMEM208
     1  MAPKGKVGTR GKKQIFEENR ETLKFYLRII LGANAIYCLV TLVFFYSSAS FWAWLALGFS
    61  LAVYGASYHS MSSMARAAFS EDGALMDGGM DLNMEQGMAE HLKDVILLTA IVQVLSCFSL
   121  YVWSFWLLAP GRALYLLWVN VLGPWFTADS GTPAPEHNEK RQRRQERRQM KRL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TMEM208 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 3
Mean surface accessibility (rSASA): 0.4
Highest tissue expression: 126 nTPM

Expression across tissuesHPA

Tissue

choroid plexus: 126 nTPM
liver: 122 nTPM
adrenal gland: 81 nTPM
pancreas: 64 nTPM
parathyroid gland: 63 nTPM
pituitary gland: 62 nTPM

Single-cell type

plasma cells: 269 nCPM
hepatocytes: 250 nCPM
extravillous trophoblasts: 181 nCPM
epididymal principal cells: 173 nCPM
syncytiotrophoblasts: 169 nCPM
esophageal suprabasal cells: 162 nCPM

Immune cell

plasmacytoid DC: 169 nTPM
classical monocyte: 109 nTPM
intermediate monocyte: 103 nTPM
total PBMC: 94 nTPM
myeloid DC: 85 nTPM
non-classical monocyte: 82 nTPM

Brain region

choroid plexus: 37 nTPM
hypothalamus: 25 nTPM
midbrain: 25 nTPM
white matter: 25 nTPM
pons: 23 nTPM
thalamus: 23 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.08
gnomAD pLI: 0
gnomAD missense Z: 0.57
DepMap mean gene effect: -0.08
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

SRP-independent targeting protein 2/TMEM208
SRP-independent targeting protein 2/TMEM208

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TMEM208 as an antibody target. Whether an autoantibody or antibody against TMEM208 could matter depends on whether native TMEM208 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TMEM208 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TMEM208 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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