Seroatlas · Human Serome Atlas

TMEM204

Transmembrane protein 204

Also known as: C16orf30, CLP24, FLJ20898, TM204_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BSN7
Gene: TMEM204
Ensembl: ENSG00000131634
Chromosome: 16
Canonical length: 226 aa
Protein class: Predicted membrane proteins, Transporters

OverviewNCBI Gene

C16ORF30 plays a role in cell adhesion and cellular permeability at adherens junctions (Kearsey et al., 2004 [PubMed 15206924]).[supplied by OMIM, Mar 2008]

Canonical amino-acid sequenceUniProt

226 residues, UniProt reviewed canonical sequence.

>Q9BSN7|TMEM204
     1  MTVQRLVAAA VLVALVSLIL NNVAAFTSNW VCQTLEDGRR RSVGLWRSCW LVDRTRGGPS
    61  PGARAGQVDA HDCEALGWGS EAAGFQESRG TVKLQFDMMR ACNLVATAAL TAGQLTFLLG
   121  LVGLPLLSPD APCWEEAMAA AFQLASFVLV IGLVTFYRIG PYTNLSWSCY LNIGACLLAT
   181  LAAAMLIWNI LHKREDCMAP RVIVISRSLT ARFRRGLDND YVESPC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TMEM204 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 4
Mean surface accessibility (rSASA): 0.39
Highest tissue expression: 73 nTPM

Expression across tissuesHPA

Tissue

heart muscle: 73 nTPM
lung: 72 nTPM
blood vessel: 71 nTPM
thyroid gland: 50 nTPM
adipose tissue: 49 nTPM
kidney: 48 nTPM

Single-cell type

vascular endothelial cells: 133 nCPM
pericytes: 84 nCPM
hepatic stellate cells: 84 nCPM
lymphatic endothelial cells: 82 nCPM
medullary thymic epithelial cells: 74 nCPM
peritubular myoid cells: 72 nCPM

Immune cell

naive CD4 T-cell: 157 nTPM
naive CD8 T-cell: 83 nTPM
memory CD4 T-cell: 80 nTPM
memory CD8 T-cell: 55 nTPM
MAIT T-cell: 45 nTPM
total PBMC: 41 nTPM

Brain region

thalamus: 22 nTPM
pons: 20 nTPM
amygdala: 19 nTPM
midbrain: 18 nTPM
medulla oblongata: 16 nTPM
basal ganglia: 16 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.38
gnomAD pLI: 0.91
gnomAD missense Z: 0.99
DepMap mean gene effect: 0
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

Transmembrane protein 204

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TMEM204 as an antibody target. Whether an autoantibody or antibody against TMEM204 could matter depends on whether native TMEM204 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TMEM204 is annotated at the cell surface, where native TMEM204 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label TMEM204 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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