Seroatlas · Human Serome Atlas

TMEM202

Transmembrane protein 202

Also known as: FLJ27523, TM202_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A6NGA9
Gene: TMEM202
Ensembl: ENSG00000187806
Chromosome: 15
Canonical length: 273 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins, Transporters

OverviewNCBI Gene

Predicted to be located in membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

273 residues, UniProt reviewed canonical sequence.

>A6NGA9|TMEM202
     1  MERREHLTLT FHSPEVPKIK GNRKYQRPTV PAKKHPSASM SCQRQQQLMD QAHIYIRTLC
    61  GSLCSFSLLM LIAMSPLNWV QFLVIKNGLE LYAGLWTLCN HELCWSHTPK PPYYLQYSRA
   121  FFLISVFTIL TGLGWLFSSW ILNRGSMTTN LDLKVSMLSF ISATCLLLCL NLFVAQVHWH
   181  TRDAMESDLL WTYYLNWCSD IFYMFAGIIS LLNYLTSRSP ACDENVTVIP TERSRLGVGP
   241  VTTVSPAKDE GPRSEMESLS VREKNLPKSG LWW

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TMEM202 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 4
Mean surface accessibility (rSASA): 0.44
Highest tissue expression: 12 nTPM

Expression across tissuesHPA

Tissue

testis: 12 nTPM
adipose tissue: 0 nTPM
adrenal gland: 0 nTPM
amygdala: 0 nTPM
appendix: 0 nTPM
basal ganglia: 0 nTPM

Single-cell type

late primary spermatocytes: 150 nCPM
late spermatids: 93 nCPM
early spermatids: 67 nCPM
early primary spermatocytes: 8.5 nCPM
differentiating spermatogonia: 1.4 nCPM
sertoli cells: 1.4 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebral cortex: 0.3 nTPM
basal ganglia: 0.2 nTPM
midbrain: 0.2 nTPM
cerebellum: 0.1 nTPM
hippocampal formation: 0.1 nTPM
medulla oblongata: 0.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.51
gnomAD pLI: 0
gnomAD missense Z: 0.23
DepMap mean gene effect: 0.07
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

plasma membrane

Protein domainsUniProt · Pfam · InterPro

Peripheral myelin protein 22/Epithelial membrane protein-like

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TMEM202 as an antibody target. Whether an autoantibody or antibody against TMEM202 could matter depends on whether native TMEM202 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TMEM202 is annotated at the cell surface, where native TMEM202 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label TMEM202 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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