Seroatlas · Human Serome Atlas

TMEM201

Transmembrane protein 201

Also known as: Ima1, NET5, RP13-15M17.2, SAMP1, TM201_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q5SNT2
Gene
TMEM201
Ensembl
ENSG00000188807
Chromosome
1
Canonical length
666 aa
Protein class
Predicted membrane proteins, Transporters
Subcellular location
Nucleoplasm,Nuclear membrane

OverviewNCBI Gene

Predicted to enable actin filament binding activity and lamin binding activity. Involved in several processes, including centrosome localization; positive regulation of endothelial cell migration; and protein localization to nuclear envelope. Located in cortical endoplasmic reticulum; nuclear inner membrane; and spindle pole centrosome. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

666 residues, UniProt reviewed canonical sequence.

>Q5SNT2|TMEM201
     1  MEGVSALLAR CPTAGLAGGL GVTACAAAGV LLYRIARRMK PTHTMVNCWF CNQDTLVPYG
    61  NRNCWDCPHC EQYNGFQENG DYNKPIPAQY LEHLNHVVSS APSLRDPSQP QQWVSSQVLL
   121  CKRCNHHQTT KIKQLAAFAP REEGRYDEEV EVYRHHLEQM YKLCRPCQAA VEYYIKHQNR
   181  QLRALLLSHQ FKRREADQTH AQNFSSAVKS PVQVILLRAL AFLACAFLLT TALYGASGHF
   241  APGTTVPLAL PPGGNGSATP DNGTTPGAEG WRQLLGLLPE HMAEKLCEAW AFGQSHQTGV
   301  VALGLLTCLL AMLLAGRIRL RRIDAFCTCL WALLLGLHLA EQHLQAASPS WLDTLKFSTT
   361  SLCCLVGFTA AVATRKATGP RRFRPRRFFP GDSAGLFPTS PSLAIPHPSV GGSPASLFIP
   421  SPPSFLPLAN QQLFRSPRRT SPSSLPGRLS RALSLGTIPS LTRADSGYLF SGSRPPSQVS
   481  RSGEFPVSDY FSLLSGSCPS SPLPSPAPSV AGSVASSSGS LRHRRPLISP ARLNLKGQKL
   541  LLFPSPPGEA PTTPSSSDEH SPHNGSLFTM EPPHVPRKPP LQDVKHALDL RSKLERGSAC
   601  SNRSIKKEDD SSQSSTCVVD TTTRGCSEEA ATWRGRFGPS LVRGLLAVSL AANALFTSVF
   661  LYQSLR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TMEM201 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
5
Mean surface accessibility (rSASA)
0.54
Highest tissue expression
41 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 41 nTPM
  • tongue: 23 nTPM
  • pituitary gland: 15 nTPM
  • heart muscle: 14 nTPM
  • cerebellum: 10 nTPM
  • cerebral cortex: 9.9 nTPM

Single-cell type

  • cone photoreceptor cells: 17 nCPM
  • rod photoreceptor cells: 16 nCPM
  • retinal bipolar cells: 14 nCPM
  • hepatic stellate cells: 13 nCPM
  • oligodendrocyte progenitor cells: 13 nCPM
  • respiratory deuterosomal cells: 11 nCPM

Immune cell

  • plasmacytoid DC: 1.3 nTPM
  • memory B-cell: 0.5 nTPM
  • memory CD8 T-cell: 0.5 nTPM
  • T-reg: 0.5 nTPM
  • gdT-cell: 0.3 nTPM
  • memory CD4 T-cell: 0.3 nTPM

Brain region

  • medulla oblongata: 24 nTPM
  • midbrain: 23 nTPM
  • pons: 22 nTPM
  • thalamus: 22 nTPM
  • cerebral cortex: 22 nTPM
  • hippocampal formation: 21 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.29
gnomAD pLI
0.99
gnomAD missense Z
1.33
DepMap mean gene effect
-0.15
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Ima1, N-terminal domain
  • Transmembrane protein 201, C-terminal
  • Transmembrane protein 201
  • Ima1 N-terminal domain
  • Protein of unknown function C-terminus (DUF2448)

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TMEM201 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TMEM201 as an antibody target. Whether an autoantibody or antibody against TMEM201 could matter depends on whether native TMEM201 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TMEM201 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TMEM201 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TMEM201. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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