Seroatlas · Human Serome Atlas

TMEM200C

Transmembrane protein 200C

Also known as: T200C_HUMAN, TTMA

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A6NKL6
Gene: TMEM200C
Ensembl: ENSG00000206432
Chromosome: 18
Canonical length: 621 aa
Protein class: Predicted membrane proteins
Subcellular location: Microtubules

OverviewNCBI Gene

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

621 residues, UniProt reviewed canonical sequence.

>A6NKL6|TMEM200C
     1  MIATGGLLRI SARKQDPLRP PSQIPKRKRK AKKRRKNDVV VVKGKLKLCS ISGLIALCGI
    61  LVLLVGIAMA VVGYWPKATG TNREGGKQLP PAGSSHRVPT TANSSSSGSK NRSRSHPRAP
   121  GGVNSSSAGA PRSTPPARAA SPSSSSTSVG FFFRIFSGYL HSDKLKVFGP LIMGIGIFLF
   181  ICANAVLHEN RDKKTKIINL RDLYSTVIDV HSLRAKDLAA AAAAAAAAAA SSSSSAPAAA
   241  PPGAIPLNGF LSYVQSRGLE LKPGGCGGSG DAFGAAAMLA KGSWPPHPAA PSGGRPRGAA
   301  SPPDLASSPR CPREPPSLAE AVYSVYRERS GVAGSRRAAA ATAAAAASSC SSPAPCSPPE
   361  SWGRQSTASS FVDSSLSAFA LLPLQGGRDR GGDAEGASCS WQRPPGERGS QEIPRGELDL
   421  SMTNLRGAEG SMRGARREPE EPEGAVAARA ARGQGGRLPR TGRYAALRRR STSGLPDYRA
   481  PPSPEPPPSP GSADPDSSPL AKAASPSPPL RLEGSPPTRR DSGSSQSDDP SSSNKGYTPL
   541  REAGTSTESV LDAVAGQTRD SAVAAPVLGA EQSSPEGASQ EPPTAEQPQP VQRQFTNKEK
   601  LIMISRSHAI GVEEELESTG I

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TMEM200C can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 2
Mean surface accessibility (rSASA): 0.68
Highest tissue expression: 5.5 nTPM

Expression across tissuesHPA

Tissue

salivary gland: 5.5 nTPM
adrenal gland: 3.7 nTPM
cerebral cortex: 3.2 nTPM
hypothalamus: 2.3 nTPM
midbrain: 2.3 nTPM
pituitary gland: 2.1 nTPM

Single-cell type

podocytes: 36 nCPM
retinal amacrine cells: 27 nCPM
oligodendrocyte progenitor cells: 26 nCPM
bergmann glia: 15 nCPM
brain inhibitory neurons: 14 nCPM
adrenal medulla cells: 11 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

midbrain: 11 nTPM
hypothalamus: 4.6 nTPM
pons: 4.6 nTPM
spinal cord: 4.6 nTPM
basal ganglia: 4.4 nTPM
cerebral cortex: 4.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.24
gnomAD pLI: 0.11
gnomAD missense Z: -0.1
DepMap mean gene effect: 0.11
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TMEM200C as an antibody target. Whether an autoantibody or antibody against TMEM200C could matter depends on whether native TMEM200C is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TMEM200C is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TMEM200C as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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