Seroatlas · Human Serome Atlas

TMEM200B

Transmembrane protein 200B

Also known as: T200B_HUMAN, TTMB

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q69YZ2
Gene: TMEM200B
Ensembl: ENSG00000253304
Chromosome: 1
Canonical length: 307 aa
Protein class: Predicted membrane proteins

OverviewNCBI Gene

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

307 residues, UniProt reviewed canonical sequence.

>Q69YZ2|TMEM200B
     1  MTAGSPEECG EVRRSPEGRV SRLGRRLGRR RRPRSPPEPL RVRARLRLRS PSGAFAALGA
    61  LVVLVGMGIA VAGYWPHRAG APGSRAANAS SPQMSELRRE GRGGGRAHGP HERLRLLGPV
   121  IMGVGLFVFI CANTLLYENR DLETRRLRQG VLRAQALRPP DGPGWDCALL PSPGPRSPRA
   181  VGCAEPEIWD PSPRRGTSPV PSVRSLRSEP ANPRLGLPAL LNSYPLKGPG LPPPWGPRTQ
   241  TGHVIITVQP SGSCIEHSKS LDLGLGELLL GAPAARDCAH RSWPRLDRLS LGGYAKLGGG
   301  GDLGARV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TMEM200B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 2
Mean surface accessibility (rSASA): 0.67
Highest tissue expression: 58 nTPM

Expression across tissuesHPA

Tissue

endometrium: 58 nTPM
cervix: 47 nTPM
seminal vesicle: 37 nTPM
smooth muscle: 33 nTPM
ovary: 32 nTPM
colon: 29 nTPM

Single-cell type

cardiomyocytes: 18 nCPM
peritubular myoid cells: 15 nCPM
adipocytes: 13 nCPM
leydig cells: 13 nCPM
decidual stromal cells: 12 nCPM
vascular smooth muscle cells: 12 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebellum: 12 nTPM
choroid plexus: 11 nTPM
basal ganglia: 10 nTPM
cerebral cortex: 2.9 nTPM
thalamus: 2.8 nTPM
hypothalamus: 2.5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.38
gnomAD pLI: 0
gnomAD missense Z: 0.24
DepMap mean gene effect: -0.01
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TMEM200B as an antibody target. Whether an autoantibody or antibody against TMEM200B could matter depends on whether native TMEM200B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TMEM200B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TMEM200B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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