Seroatlas · Human Serome Atlas

TMEM200A

Transmembrane protein 200A

Also known as: KIAA1913, T200A_HUMAN, TTMC

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q86VY9
Gene: TMEM200A
Ensembl: ENSG00000164484
Chromosome: 6
Canonical length: 491 aa
Protein class: Predicted membrane proteins

OverviewNCBI Gene

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

491 residues, UniProt reviewed canonical sequence.

>Q86VY9|TMEM200A
     1  MIATGGVITG LAALKRQDSA RSQQHVNLSP SPATQEKKPI RRRPRADVVV VRGKIRLYSP
    61  SGFFLILGVL ISIIGIAMAV LGYWPQKEHF IDAETTLSTN ETQVIRNEGG VVVRFFEQHL
   121  HSDKMKMLGP FTMGIGIFIF ICANAILHEN RDKETKIIHM RDIYSTVIDI HTLRIKEQRQ
   181  MNGMYTGLMG ETEVKQNGSS CASRLAANTI ASFSGFRSSF RMDSSVEEDE LMLNEGKSSG
   241  HLMPPLLSDS SVSVFGLYPP PSKTTDDKTS GSKKCETKSI VSSSISAFTL PVIKLNNCVI
   301  DEPSIDNITE DADNLKSRSR NLSMDSLVVP LPNTSESFQP VSTVLPRNNS IGESLSSQYK
   361  SSMALGPGAG QLLSPGAARR QFGSNTSLHL LSSHSKSLDL DRGPSTLTVQ AEQRKHPSWP
   421  RLDRNNSKGY MKLENKEDPM DRLLVPQVAI KKDFTNKEKL LMISRSHNNL SFEHDEFLSN
   481  NLKRGTSETR F

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TMEM200A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 2
Mean surface accessibility (rSASA): 0.66
Highest tissue expression: 37 nTPM

Expression across tissuesHPA

Tissue

endometrium: 37 nTPM
rectum: 21 nTPM
smooth muscle: 18 nTPM
adrenal gland: 16 nTPM
fallopian tube: 13 nTPM
kidney: 13 nTPM

Single-cell type

retinal bipolar cells: 69 nCPM
pancreatic islet cells: 62 nCPM
neuroendocrine cells: 59 nCPM
lactotrophs: 58 nCPM
gonadotrophs: 49 nCPM
endometrial stromal cells: 42 nCPM

Immune cell

NK-cell: 4 nTPM
memory CD4 T-cell: 0.8 nTPM
MAIT T-cell: 0.4 nTPM
memory CD8 T-cell: 0.4 nTPM
gdT-cell: 0.3 nTPM
memory B-cell: 0.2 nTPM

Brain region

hippocampal formation: 10 nTPM
midbrain: 10 nTPM
hypothalamus: 8.9 nTPM
cerebral cortex: 6 nTPM
amygdala: 4.3 nTPM
pons: 3.8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.45
gnomAD pLI: 0.85
gnomAD missense Z: 0.66
DepMap mean gene effect: 0.06
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TMEM200A as an antibody target. Whether an autoantibody or antibody against TMEM200A could matter depends on whether native TMEM200A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TMEM200A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TMEM200A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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