Seroatlas · Human Serome Atlas

TMEM198

Transmembrane protein 198

Also known as: MGC99813, TM198_HUMAN, TMEM198A

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q66K66
Gene: TMEM198
Ensembl: ENSG00000188760
Chromosome: 2
Canonical length: 360 aa
Protein class: Predicted membrane proteins
Subcellular location: Vesicles

OverviewNCBI Gene

Involved in positive regulation of canonical Wnt signaling pathway. Located in cytoplasmic vesicle and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

360 residues, UniProt reviewed canonical sequence.

>Q66K66|TMEM198
     1  MPGTVATLRF QLLPPEPDDA FWGAPCEQPL ERRYQALPAL VCIMCCLFGV VYCFFGYRCF
    61  KAVLFLTGLL FGSVVIFLLC YRERVLETQL SAGASAGIAL GIGLLCGLVA MLVRSVGLFL
   121  VGLLLGLLLA AAALLGSAPY YQPGSVWGPL GLLLGGGLLC ALLTLRWPRP LTTLATAVTG
   181  AALIATAADY FAELLLLGRY VVERLRAAPV PPLCWRSWAL LALWPLLSLM GVLVQWRVTA
   241  EGDSHTEVVI SRQRRRVQLM RIRQQEDRKE KRRKKRPPRA PLRGPRAPPR PGPPDPAYRR
   301  RPVPIKRFNG DVLSPSYIQS FRDRQTGSSL SSFMASPTDA DYEYGSRGPL TACSGPPVRV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TMEM198 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.42
Highest tissue expression: 17 nTPM

Expression across tissuesHPA

Tissue

pituitary gland: 17 nTPM
cerebellum: 15 nTPM
cerebral cortex: 15 nTPM
hippocampal formation: 14 nTPM
ovary: 14 nTPM
basal ganglia: 11 nTPM

Single-cell type

tuft cells: 46 nCPM
adrenal medulla cells: 43 nCPM
epicardial cells: 41 nCPM
cardiomyocytes: 26 nCPM
neuroendocrine cells: 16 nCPM
decidual stromal cells: 16 nCPM

Immune cell

plasmacytoid DC: 0.4 nTPM
NK-cell: 0.1 nTPM
total PBMC: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM

Brain region

hippocampal formation: 44 nTPM
cerebral cortex: 40 nTPM
cerebellum: 25 nTPM
amygdala: 22 nTPM
basal ganglia: 20 nTPM
hypothalamus: 18 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.56
gnomAD pLI: 0.41
gnomAD missense Z: 1.03
DepMap mean gene effect: 0
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TMEM198 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

LRP6

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TMEM198 as an antibody target. Whether an autoantibody or antibody against TMEM198 could matter depends on whether native TMEM198 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TMEM198 is annotated at the cell surface, where native TMEM198 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label TMEM198 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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