Seroatlas · Human Serome Atlas

TMEM191C

Transmembrane protein 191C

Also known as: T191C_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
A6NGB0
Gene
TMEM191C
Ensembl
ENSG00000206140
Chromosome
22
Canonical length
302 aa
Protein class
Predicted membrane proteins

OverviewNCBI Gene

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

302 residues, UniProt reviewed canonical sequence.

>A6NGB0|TMEM191C
     1  MAATQELLLQ LQKDNRDGRQ RKQELEKLMR GLEAESESLN QRLQDLSERE RSLLRRRSQA
    61  AQPLQGEARE AARERAERVR RRLEEAERHK EYLEQHSRQL QEQWEELSSQ LFYYGGELQS
   121  QKSTEQQLAA QLVTLQNELE LAETKCALQE EKLQQDALQT AEAWAIFQEQ TVVLQEVQVK
   181  VMEAAEELDA WQSGRELCDG QLRGVQYSTE SLMEEMARAD RETRLFGGPR ALAIRRCVLG
   241  ALQVLLTLPL LFLGLSLLWT VLLDPGAVSA WLWSLTSETT LRRLRYTLSP LLELRANGLL
   301  PT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TMEM191C can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.52
Highest tissue expression
39 nTPM

Expression across tissuesHPA

Tissue

  • testis: 39 nTPM
  • amygdala: 0.6 nTPM
  • hippocampal formation: 0.6 nTPM
  • cerebral cortex: 0.5 nTPM
  • hypothalamus: 0.5 nTPM
  • pituitary gland: 0.5 nTPM

Single-cell type

  • late spermatids: 1,295 nCPM
  • early spermatids: 801 nCPM
  • late primary spermatocytes: 139 nCPM
  • cytotrophoblasts: 47 nCPM
  • migrating cytotrophoblasts: 29 nCPM
  • esophageal apical cells: 26 nCPM

Immune cell

  • total PBMC: 0.2 nTPM
  • naive CD8 T-cell: 0.1 nTPM
  • non-classical monocyte: 0.1 nTPM
  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM

Brain region

  • cerebral cortex: 0.2 nTPM
  • pons: 0.2 nTPM
  • white matter: 0.2 nTPM
  • hypothalamus: 0.1 nTPM
  • amygdala: 0 nTPM
  • basal ganglia: 0 nTPM

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TMEM191C as an antibody target. Whether an autoantibody or antibody against TMEM191C could matter depends on whether native TMEM191C is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TMEM191C is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TMEM191C as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TMEM191C. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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