Seroatlas · Human Serome Atlas

TMEM191B

Transmembrane protein 191B

Also known as: T191B_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P0C7N4
Gene
TMEM191B
Ensembl
ENSG00000278558
Chromosome
22
Canonical length
346 aa
Protein class
Predicted membrane proteins

OverviewNCBI Gene

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

346 residues, UniProt reviewed canonical sequence.

>P0C7N4|TMEM191B
     1  MCRATLGLPL PPIVIQPARR SLPPIVTPAS RRLGPRGGRH LGSVSTAMAA TQELLLQLQK
    61  DNRDGRQRKQ ELEKLMRGLE AESESLNQRL QDLSERERSL LRRRSQAAQP LQGEAREAAR
   121  ERAERVRRRL EEAERHKEDL EQHSRQLQEQ WEELSSQLFY GGEPQSQKST EQQLAAQLVT
   181  LQNELELAET KCALQEEKLQ QDALQTAEAW AIFQEQTVVL QVRPHSDAKV PPASPPPDLG
   241  RCDGQLRGVQ YSTESLMEEM ARADRETRLF GGPRALAIRR CVLGALQVLL TLPLLFLGLS
   301  LLWTVLLDPG AVSAWLWSLT SETTLRRLRY TLSPLLELRA NGLLPT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TMEM191B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.54
Highest tissue expression
86 nTPM

Expression across tissuesHPA

Tissue

  • testis: 86 nTPM
  • cerebral cortex: 2.9 nTPM
  • hypothalamus: 2.5 nTPM
  • amygdala: 2.3 nTPM
  • hippocampal formation: 2.3 nTPM
  • basal ganglia: 2 nTPM

Single-cell type

  • late spermatids: 171 nCPM
  • early spermatids: 111 nCPM
  • tuft cells: 35 nCPM
  • late primary spermatocytes: 20 nCPM
  • enterocytes: 19 nCPM
  • cytotrophoblasts: 10 nCPM

Immune cell

  • intermediate monocyte: 3.4 nTPM
  • non-classical monocyte: 2.7 nTPM
  • basophil: 2.4 nTPM
  • total PBMC: 1.4 nTPM
  • classical monocyte: 1.3 nTPM
  • myeloid DC: 1.3 nTPM

Brain region

  • medulla oblongata: 3 nTPM
  • amygdala: 2.5 nTPM
  • cerebral cortex: 2.4 nTPM
  • pons: 2.3 nTPM
  • basal ganglia: 2.2 nTPM
  • thalamus: 2 nTPM

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TMEM191B as an antibody target. Whether an autoantibody or antibody against TMEM191B could matter depends on whether native TMEM191B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TMEM191B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TMEM191B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TMEM191B. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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