Seroatlas · Human Serome Atlas

TMEM191A

Transmembrane protein 191A

Also known as: T191A_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9H0A3
Gene: TMEM191A
Canonical length: 160 aa

OverviewNCBI Gene

No narrative summary is available for TMEM191A in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

160 residues, UniProt reviewed canonical sequence.

>Q9H0A3|TMEM191A
     1  MMNNTDFLML NNPWNKLCLV SMDFCFPLDF VSNLFWIFAS KFIIVTGQIK ADFKRTSWEA
    61  KAEGSLEPGR LKLQLASIVP LYSSLVTAGP ASKIIILKRT SLPTVSPSNE RAYLLPVSFT
   121  DLAHVFYLSY FSINAKSNSF SLDIIIALGI PHNTQAHFNH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TMEM191A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.57

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

membrane

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TMEM191A as an antibody target. Whether an autoantibody or antibody against TMEM191A could matter depends on whether native TMEM191A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TMEM191A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TMEM191A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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