TMEM190
Transmembrane protein 190
Also known as: MDAC1, TM190_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q8WZ59
- Gene
- TMEM190
- Ensembl
- ENSG00000160472
- Chromosome
- 19
- Canonical length
- 177 aa
- Protein class
- Predicted membrane proteins
OverviewNCBI Gene
Predicted to enable identical protein binding activity. Predicted to be involved in hematopoietic progenitor cell differentiation. Located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
177 residues, UniProt reviewed canonical sequence.
>Q8WZ59|TMEM190
1 MLGCGIPALG LLLLLQGSAD GNGIQGFFYP WSCEGDIWDR ESCGGQAAID SPNLCLRLRC
61 CYRNGVCYHQ RPDENVRRKH MWALVWTCSG LLLLSCSICL FWWAKRRDVL HMPGFLAGPC
121 DMSKSVSLLS KHRGTKKTPS TGSVPVALSK ESRDVEGGTE GEGTEEGEET EGEEEEDLocalizationUniProt · AlphaFold · HPA
Whether an antibody against TMEM190 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 1
- Mean surface accessibility (rSASA)
- 0.54
- Highest tissue expression
- 130 nTPM
Expression across tissuesHPA
Tissue
- fallopian tube: 130 nTPM
- testis: 55 nTPM
- lung: 18 nTPM
- pituitary gland: 7 nTPM
- hypothalamus: 6.1 nTPM
- cervix: 3.4 nTPM
Single-cell type
- respiratory ciliated cells: 1,781 nCPM
- fallopian tube ciliated cells: 1,011 nCPM
- early spermatids: 794 nCPM
- epididymal efferent duct ciliated cells: 511 nCPM
- endometrial ciliated cells: 391 nCPM
- late spermatids: 218 nCPM
Immune cell
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
- MAIT T-cell: 0 nTPM
Brain region
- cerebellum: 18 nTPM
- midbrain: 9.9 nTPM
- medulla oblongata: 7.7 nTPM
- pons: 6.3 nTPM
- cerebral cortex: 5.5 nTPM
- hypothalamus: 4.6 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.5
- gnomAD pLI
- 0
- gnomAD missense Z
- 0.21
- DepMap mean gene effect
- 0.01
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
- P-type trefoil domain superfamily
- Transmembrane protein 190
- Transmembrane protein 190
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads TMEM190 as an antibody target. Whether an autoantibody or antibody against TMEM190 could matter depends on whether native TMEM190 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
TMEM190 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label TMEM190 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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