Seroatlas · Human Serome Atlas

TMEM19

Transmembrane protein 19

Also known as: FLJ10936, TMM19_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96HH6
Gene: TMEM19
Ensembl: ENSG00000139291
Chromosome: 12
Canonical length: 336 aa
Protein class: Predicted membrane proteins

OverviewNCBI Gene

Predicted to be active in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

336 residues, UniProt reviewed canonical sequence.

>Q96HH6|TMEM19
     1  MTDLNDNICK RYIKMITNIV ILSLIICISL AFWIISMTAS TYYGNLRPIS PWRWLFSVVV
    61  PVLIVSNGLK KKSLDHSGAL GGLVVGFILT IANFSFFTSL LMFFLSSSKL TKWKGEVKKR
   121  LDSEYKEGGQ RNWVQVFCNG AVPTELALLY MIENGPGEIP VDFSKQYSAS WMCLSLLAAL
   181  ACSAGDTWAS EVGPVLSKSS PRLITTWEKV PVGTNGGVTV VGLVSSLLGG TFVGIAYFLT
   241  QLIFVNDLDI SAPQWPIIAF GGLAGLLGSI VDSYLGATMQ YTGLDESTGM VVNSPTNKAR
   301  HIAGKPILDN NAVNLFSSVL IALLLPTAAW GFWPRG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TMEM19 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 6
Mean surface accessibility (rSASA): 0.26
Highest tissue expression: 36 nTPM

Expression across tissuesHPA

Tissue

kidney: 36 nTPM
duodenum: 32 nTPM
esophagus: 29 nTPM
tonsil: 29 nTPM
small intestine: 28 nTPM
colon: 25 nTPM

Single-cell type

late spermatids: 130 nCPM
esophageal suprabasal cells: 62 nCPM
plasma cells: 59 nCPM
esophageal basal cells: 59 nCPM
paneth cells: 54 nCPM
kupffer cells: 50 nCPM

Immune cell

plasmacytoid DC: 135 nTPM
naive B-cell: 119 nTPM
memory B-cell: 103 nTPM
myeloid DC: 48 nTPM
intermediate monocyte: 35 nTPM
total PBMC: 34 nTPM

Brain region

choroid plexus: 27 nTPM
white matter: 27 nTPM
spinal cord: 24 nTPM
hypothalamus: 24 nTPM
medulla oblongata: 24 nTPM
pons: 23 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.85
gnomAD pLI: 0.01
gnomAD missense Z: 0.42
DepMap mean gene effect: -0.04
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

membrane

Protein domainsUniProt · Pfam · InterPro

Protein of unknown function DUF92, TMEM19
Integral membrane protein DUF92

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TMEM19 as an antibody target. Whether an autoantibody or antibody against TMEM19 could matter depends on whether native TMEM19 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TMEM19 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TMEM19 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...