Seroatlas · Human Serome Atlas

TMEM187

Transmembrane protein 187

Also known as: CXorf12, DXS9878E, ITBA1, TM187_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q14656
Gene: TMEM187
Ensembl: ENSG00000177854
Chromosome: X
Canonical length: 261 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins, Transporters
Subcellular location: Nucleoli,Cytosol

OverviewNCBI Gene

This gene consists of two exons and encodes a multi-pass membrane protein. An alternatively spliced transcript variant encoding the same protein has been found, but its biological validity is not determined. [provided by RefSeq, May 2010]

Canonical amino-acid sequenceUniProt

261 residues, UniProt reviewed canonical sequence.

>Q14656|TMEM187
     1  MNPEWGQAFV HVAVAGGLCA VAVFTGIFDS VSVQVGYEHY AEAPVAGLPA FLAMPFNSLV
    61  NMAYTLLGLS WLHRGGAMGL GPRYLKDVFA AMALLYGPVQ WLRLWTQWRR AAVLDQWLTL
   121  PIFAWPVAWC LYLDRGWRPW LFLSLECVSL ASYGLALLHP QGFEVALGAH VVAAVGQALR
   181  THRHYGSTTS ATYLALGVLS CLGFVVLKLC DHQLARWRLF QCLTGHFWSK VCDVLQFHFA
   241  FLFLTHFNTH PRFHPSGGKT R

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TMEM187 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 6
Mean surface accessibility (rSASA): 0.28
Highest tissue expression: 15 nTPM

Expression across tissuesHPA

Tissue

pancreas: 15 nTPM
adrenal gland: 11 nTPM
choroid plexus: 11 nTPM
skin: 10 nTPM
liver: 10 nTPM
salivary gland: 10 nTPM

Single-cell type

epididymal principal cells: 29 nCPM
breast lactating cells: 20 nCPM
hepatocytes: 19 nCPM
fallopian tube ciliated cells: 19 nCPM
cytotrophoblasts: 16 nCPM
hofbauer cells: 15 nCPM

Immune cell

basophil: 32 nTPM
naive CD4 T-cell: 32 nTPM
plasmacytoid DC: 31 nTPM
T-reg: 29 nTPM
memory CD4 T-cell: 26 nTPM
memory CD8 T-cell: 23 nTPM

Brain region

choroid plexus: 14 nTPM
white matter: 12 nTPM
medulla oblongata: 9.5 nTPM
spinal cord: 9.5 nTPM
basal ganglia: 8.7 nTPM
midbrain: 8.6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.59
gnomAD pLI: 0.02
gnomAD missense Z: 0.14
DepMap mean gene effect: -0.04
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

Transmembrane protein 187
TMEM187 protein family

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TMEM187 as an antibody target. Whether an autoantibody or antibody against TMEM187 could matter depends on whether native TMEM187 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TMEM187 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TMEM187 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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