Seroatlas · Human Serome Atlas

TMEM185B

Transmembrane protein 185B

Also known as: FAM11B, FLJ20979, T185B_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9H7F4
Gene: TMEM185B
Ensembl: ENSG00000226479
Chromosome: 2
Canonical length: 350 aa
Protein class: Predicted membrane proteins
Subcellular location: Endoplasmic reticulum

OverviewNCBI Gene

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

350 residues, UniProt reviewed canonical sequence.

>Q9H7F4|TMEM185B
     1  MNPRGLFQDF NPSKFLIYTC LLLFSVLLPL RLDGIIQWSY WAVFAPIWLW KLLVVAGASV
    61  GAGVWARNPR YRTEGEACVE FKAMLIAVGI HLLLLMFEVL VCDRVERGTH FWLLVFMPLF
   121  FVSPVSVAAC VWGFRHDRSL ELEILCSVNI LQFIFIALKL DRIIHWPWLV VFVPLWILMS
   181  FLCLVVLYYI VWSLLFLRSL DVVAEQRRTH VTMAISWITI VVPLLTFEVL LVHRLDGHNT
   241  FSYVSIFVPL WLSLLTLMAT TFRRKGGNHW WFGIRRDFCQ FLLEIFPFLR EYGNISYDLH
   301  HEDSEDAEET SVPEAPKIAP IFGKKARVVI TQSPGKYVPP PPKLNIDMPD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TMEM185B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.36
Highest tissue expression: 24 nTPM

Expression across tissuesHPA

Tissue

parathyroid gland: 24 nTPM
thyroid gland: 9.6 nTPM
heart muscle: 9.3 nTPM
adipose tissue: 8.8 nTPM
esophagus: 8.8 nTPM
prostate: 8.7 nTPM

Single-cell type

extravillous trophoblasts: 47 nCPM
neutrophils: 41 nCPM
epididymal basal cells: 34 nCPM
late primary spermatocytes: 33 nCPM
hofbauer cells: 28 nCPM
epididymal clear cells: 25 nCPM

Immune cell

neutrophil: 1.5 nTPM
NK-cell: 1.4 nTPM
MAIT T-cell: 1 nTPM
eosinophil: 0.9 nTPM
gdT-cell: 0.9 nTPM
intermediate monocyte: 0.9 nTPM

Brain region

white matter: 15 nTPM
medulla oblongata: 14 nTPM
basal ganglia: 14 nTPM
spinal cord: 14 nTPM
midbrain: 14 nTPM
thalamus: 14 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.28
gnomAD pLI: 0.97
gnomAD missense Z: 1.71
DepMap mean gene effect: -0.19
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TMEM185B as an antibody target. Whether an autoantibody or antibody against TMEM185B could matter depends on whether native TMEM185B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TMEM185B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TMEM185B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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