Seroatlas · Human Serome Atlas

TMEM184C

Transmembrane protein 184C

Also known as: FLJ10846, T184C_HUMAN, TMEM34

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NVA4
Gene: TMEM184C
Ensembl: ENSG00000164168
Chromosome: 4
Canonical length: 438 aa
Protein class: Predicted membrane proteins
Subcellular location: Nucleoplasm,Vesicles

OverviewNCBI Gene

Predicted to enable transmembrane transporter activity. Predicted to be involved in transmembrane transport. Predicted to be active in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

438 residues, UniProt reviewed canonical sequence.

>Q9NVA4|TMEM184C
     1  MPCTCTWRNW RQWIRPLVAV IYLVSIVVAV PLCVWELQKL EVGIHTKAWF IAGIFLLLTI
    61  PISLWVILQH LVHYTQPELQ KPIIRILWMV PIYSLDSWIA LKYPGIAIYV DTCRECYEAY
   121  VIYNFMGFLT NYLTNRYPNL VLILEAKDQQ KHFPPLCCCP PWAMGEVLLF RCKLGVLQYT
   181  VVRPFTTIVA LICELLGIYD EGNFSFSNAW TYLVIINNMS QLFAMYCLLL FYKVLKEELS
   241  PIQPVGKFLC VKLVVFVSFW QAVVIALLVK VGVISEKHTW EWQTVEAVAT GLQDFIICIE
   301  MFLAAIAHHY TFSYKPYVQE AEEGSCFDSF LAMWDVSDIR DDISEQVRHV GRTVRGHPRK
   361  KLFPEDQDQN EHTSLLSSSS QDAISIASSM PPSPMGHYQG FGHTVTPQTT PTTAKISDEI
   421  LSDTIGEKKE PSDKSVDS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TMEM184C can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.38
Highest tissue expression: 124 nTPM

Expression across tissuesHPA

Tissue

parathyroid gland: 124 nTPM
thyroid gland: 31 nTPM
adrenal gland: 20 nTPM
liver: 19 nTPM
kidney: 19 nTPM
placenta: 18 nTPM

Single-cell type

epicardial cells: 894 nCPM
innate lymphoid cells: 234 nCPM
pdcs: 130 nCPM
thymocytes: 99 nCPM
cardiomyocytes: 97 nCPM
early spermatids: 91 nCPM

Immune cell

basophil: 20 nTPM
MAIT T-cell: 19 nTPM
non-classical monocyte: 18 nTPM
intermediate monocyte: 17 nTPM
myeloid DC: 16 nTPM
gdT-cell: 15 nTPM

Brain region

cerebral cortex: 45 nTPM
white matter: 35 nTPM
choroid plexus: 34 nTPM
hippocampal formation: 34 nTPM
cerebellum: 33 nTPM
thalamus: 33 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.52
gnomAD pLI: 0.07
gnomAD missense Z: 2.57
DepMap mean gene effect: -0.05
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

transmembrane transporter activity

Cellular components

membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TMEM184C as an antibody target. Whether an autoantibody or antibody against TMEM184C could matter depends on whether native TMEM184C is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TMEM184C is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TMEM184C as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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