Seroatlas · Human Serome Atlas

TMEM184B

Transmembrane protein 184B

Also known as: C22orf5, DKFZP586A1024, FM08, HS5O6A, T184B_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9Y519
Gene: TMEM184B
Ensembl: ENSG00000198792
Chromosome: 22
Canonical length: 407 aa
Protein class: Predicted membrane proteins, Transporters
Subcellular location: Nucleoplasm,Golgi apparatus,Cytosol

OverviewNCBI Gene

Predicted to enable transmembrane transporter activity. Predicted to be involved in transmembrane transport. Predicted to be active in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

407 residues, UniProt reviewed canonical sequence.

>Q9Y519|TMEM184B
     1  MTVRGDVLAP DPASPTTAAA SPSVSVIPEG SPTAMEQPVF LMTTAAQAIS GFFVWTALLI
    61  TCHQIYMHLR CYSCPNEQRY IVRILFIVPI YAFDSWLSLL FFTNDQYYVY FGTVRDCYEA
   121  LVIYNFLSLC YEYLGGESSI MSEIRGKPIE SSCMYGTCCL WGKTYSIGFL RFCKQATLQF
   181  CVVKPLMAVS TVVLQAFGKY RDGDFDVTSG YLYVTIIYNI SVSLALYALF LFYFATRELL
   241  SPYSPVLKFF MVKSVIFLSF WQGMLLAILE KCGAIPKIHS ARVSVGEGTV AAGYQDFIIC
   301  VEMFFAALAL RHAFTYKVYA DKRLDAQGRC APMKSISSSL KETMNPHDIV QDAIHNFSPA
   361  YQQYTQQSTL EPGPTWRGGA HGLSRSHSLS GARDNEKTLL LSSDDEF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TMEM184B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.36
Highest tissue expression: 68 nTPM

Expression across tissuesHPA

Tissue

spinal cord: 68 nTPM
cerebral cortex: 66 nTPM
cerebellum: 45 nTPM
hippocampal formation: 42 nTPM
midbrain: 40 nTPM
amygdala: 39 nTPM

Single-cell type

müller glia: 170 nCPM
somatotrophs: 169 nCPM
thyrotrophs: 167 nCPM
syncytiotrophoblasts: 154 nCPM
bergmann glia: 140 nCPM
endometrial luminal cells: 137 nCPM

Immune cell

basophil: 14 nTPM
neutrophil: 11 nTPM
plasmacytoid DC: 7 nTPM
NK-cell: 6.2 nTPM
gdT-cell: 5.3 nTPM
eosinophil: 4.7 nTPM

Brain region

white matter: 137 nTPM
medulla oblongata: 119 nTPM
thalamus: 117 nTPM
midbrain: 116 nTPM
pons: 116 nTPM
cerebellum: 114 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.51
gnomAD pLI: 0.37
gnomAD missense Z: 2.06
DepMap mean gene effect: -0.01
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

transmembrane transporter activity

Cellular components

membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TMEM184B as an antibody target. Whether an autoantibody or antibody against TMEM184B could matter depends on whether native TMEM184B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TMEM184B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TMEM184B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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