TMEM184A
Transmembrane protein 184A
Also known as: MGC9712, SDMG1, T184A_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q6ZMB5
- Gene
- TMEM184A
- Ensembl
- ENSG00000164855
- Chromosome
- 7
- Canonical length
- 413 aa
- Protein class
- Predicted membrane proteins, Transporters
- Subcellular location
- Nucleoplasm
OverviewNCBI Gene
Predicted to enable heparin binding activity and transmembrane transporter activity. Predicted to be involved in transmembrane transport. Predicted to act upstream of or within germ-line sex determination; regulation of protein localization; and regulation of secretion. Predicted to be located in cytoplasmic vesicle; perinuclear region of cytoplasm; and plasma membrane. Predicted to be active in early endosome membrane. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
413 residues, UniProt reviewed canonical sequence.
>Q6ZMB5|TMEM184A
1 MSNVSGILET AGVPLVSANW PQPSPPPAVP AGPQMDHMGN SSQGAPWLFL TSALARGVSG
61 IFVWTALVLT CHQIYLHLRS YTVPQEQRYI IRLLLIVPIY AFDSWLSLLL LGDHQYYVYF
121 DSVRDCYEAF VIYSFLSLCF QYLGGEGAIM AEIRGKPIKS SCLYGTCCLR GMTYSIGFLR
181 FCKQATLQFC LVKPVMAVTT IILQAFGKYH DGDFNVRSGY LYVTLIYNAS VSLALYALFL
241 FYFTTRELLR PFQPVLKFLT IKAVIFLSFW QGLLLAILER CGVIPEVETS GGNKLGAGTL
301 AAGYQNFIIC VEMLFASVAL RYAFPCQVYA EKKENSPAPP APMQSISSGI RETVSPQDIV
361 QDAIHNFSPA YQHYTQQATH EAPRPGTHPS GGSGGSRKSR SLEKRMLIPS EDLLocalizationUniProt · AlphaFold · HPA
Whether an antibody against TMEM184A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Cell surface
- Secreted
- No
- Transmembrane segments
- 7
- Mean surface accessibility (rSASA)
- 0.37
- Highest tissue expression
- 88 nTPM
Expression across tissuesHPA
Tissue
- esophagus: 88 nTPM
- vagina: 38 nTPM
- skin: 35 nTPM
- cervix: 33 nTPM
- duodenum: 23 nTPM
- liver: 23 nTPM
Single-cell type
- esophageal apical cells: 413 nCPM
- cardiomyocytes: 166 nCPM
- epicardial cells: 134 nCPM
- esophageal suprabasal cells: 132 nCPM
- enterocytes: 64 nCPM
- prostatic hillock cells: 62 nCPM
Immune cell
- neutrophil: 0.2 nTPM
- basophil: 0.1 nTPM
- plasmacytoid DC: 0.1 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
Brain region
- cerebral cortex: 3.3 nTPM
- medulla oblongata: 1.9 nTPM
- choroid plexus: 1.8 nTPM
- hypothalamus: 1.8 nTPM
- cerebellum: 1.6 nTPM
- pons: 1.6 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.37
- gnomAD pLI
- 0
- gnomAD missense Z
- -0.5
- DepMap mean gene effect
- 0.09
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads TMEM184A as an antibody target. Whether an autoantibody or antibody against TMEM184A could matter depends on whether native TMEM184A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
TMEM184A is annotated at the cell surface, where native TMEM184A is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.
Annotation status
The present source text does not explicitly label TMEM184A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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