Seroatlas · Human Serome Atlas

TMEM183BP

Putative transmembrane protein 183BP

Also known as: T183B_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q1AE95
Gene: TMEM183BP
Canonical length: 376 aa

OverviewNCBI Gene

No narrative summary is available for TMEM183BP in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

376 residues, UniProt reviewed canonical sequence.

>Q1AE95|TMEM183BP
     1  MARGPGPLGR PRPDTVAMPK RGKRLKFRAH DACSGRVTVA DYADSDLAVV RSGRVKKAVA
    61  NAVRQEVKSL CGLEASQVPA EEALSGAGEP YDIIDSSDEM DAQEENIHER TVSRKKKSKR
   121  HKEELDGAGG EEYPMDIWLL LASYIRPEDI VNFSLICKNA WTVTCTAAFW TRLYRRHYTL
   181  DASLPLRLRP ESMEKLHCLR ACVIRSLYHM YEPFAARISK NPAIPESTPS TLKNSKCLLF
   241  WCRKIVGNRQ EPMWEFNFKF KKQSPRLKSK CTGGLQPPVQ YEDVHTNPDQ DCCLLQVTTL
   301  NFIFIPIVMG MIFTLFTINV STDMRHHRVR LVFQDSPVHG GRKLRSEQGV QVILDPVHSV
   361  RLFDWWHPQY PFSLRA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TMEM183BP can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.44

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TMEM183BP as an antibody target. Whether an autoantibody or antibody against TMEM183BP could matter depends on whether native TMEM183BP is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TMEM183BP is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TMEM183BP as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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