Seroatlas · Human Serome Atlas

TMEM183A

Transmembrane protein 183A

Also known as: C1orf37, T183A_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8IXX5
Gene: TMEM183A
Ensembl: ENSG00000163444
Chromosome: 1
Canonical length: 376 aa
Protein class: Predicted membrane proteins
Subcellular location: Nucleoplasm,Plasma membrane,Cell Junctions

OverviewNCBI Gene

Predicted to be located in membrane. Predicted to be part of SCF ubiquitin ligase complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

376 residues, UniProt reviewed canonical sequence.

>Q8IXX5|TMEM183A
     1  MARGPGPLGR PRPDTVAMPK RGKRLKFRAH DACSGRVTVA DYANSDPAVV RSGRVKKAVA
    61  NAVQQEVKSL CGLEASQVPA EEALSGAGEP CDIIDSSDEM DAQEESIHER TVSRKKKSKR
   121  HKEELDGAGG EEYPMDIWLL LASYIRPEDI VNFSLICKNA WTVTCTAAFW TRLYRRHYTL
   181  DASLPLRLRP ESMEKLRCLR ACVIRSLYHM YEPFAARISK NPAIPESTPS TLKNSKCLLF
   241  WCRKIVGNRQ EPMWEFNFKF KKQSPRLKSK CTGGLQPPVQ YEDVHTNPDQ DCCLLQVTTL
   301  NFIFIPIVMG MIFTLFTINV STDMRHHRVR LVFQDSPVHG GRKLRSEQGV QVILDPVHSV
   361  RLFDWWHPQY PFSLRA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TMEM183A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.44
Highest tissue expression: 72 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 72 nTPM
cerebellum: 41 nTPM
cerebral cortex: 41 nTPM
testis: 32 nTPM
colon: 29 nTPM
amygdala: 29 nTPM

Single-cell type

late primary spermatocytes: 117 nCPM
late spermatids: 97 nCPM
early spermatids: 76 nCPM
differentiating spermatogonia: 63 nCPM
neutrophil progenitors: 59 nCPM
enteric transient amplifying cells: 57 nCPM

Immune cell

eosinophil: 51 nTPM
myeloid DC: 37 nTPM
total PBMC: 37 nTPM
NK-cell: 37 nTPM
classical monocyte: 34 nTPM
basophil: 33 nTPM

Brain region

cerebral cortex: 43 nTPM
hypothalamus: 41 nTPM
basal ganglia: 37 nTPM
cerebellum: 36 nTPM
pons: 35 nTPM
thalamus: 33 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.43
gnomAD pLI: 0.7
gnomAD missense Z: 1.41
DepMap mean gene effect: -0.52
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 11% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TMEM183A as an antibody target. Whether an autoantibody or antibody against TMEM183A could matter depends on whether native TMEM183A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TMEM183A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TMEM183A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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