Seroatlas · Human Serome Atlas

TMEM181

Transmembrane protein 181

Also known as: GPR178, KIAA1423, TM181_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9P2C4
Gene: TMEM181
Ensembl: ENSG00000146433
Chromosome: 6
Canonical length: 475 aa
Protein class: Predicted membrane proteins, Transporters
Subcellular location: Golgi apparatus,Vesicles

OverviewNCBI Gene

The TMEM181 gene encodes a putative G protein-coupled receptor expressed on the cell surface (Carette et al., 2009 [PubMed 19965467]; Wollscheid et al., 2009 [PubMed 19349973]).[supplied by OMIM, Jan 2010]

Canonical amino-acid sequenceUniProt

475 residues, UniProt reviewed canonical sequence.

>Q9P2C4|TMEM181
     1  MEPLAPMRLY TLSKRHFVLV FVVFFICFGL TIFVGIRGPK VIQTSAANFS LNNSKKLKPI
    61  QILSNPLSTY NQQLWLTCVV ELDQSKETSI KTSFPMTVKV DGVAQDGTTM YIHNKVHNRT
   121  RTLTCAGKCA EIIVAHLGYL NYTQYTVIVG FEHLKLPIKG MNFTWKTYNP AFSRLEIWFR
   181  FFFVVLTFIV TCLFAHSLRK FSMRDWGIEQ KWMSVLLPLL LLYNDPFFPL SFLVNSWLPG
   241  MLDDLFQSMF LCALLLFWLC VYHGIRVQGE RKCLTFYLPK FFIVGLLWLA SVTLGIWQTV
   301  NELHDPMYQY RVDTGNFQGM KVFFMVVAAV YILYLLFLIV RACSELRHMP YVDLRLKFLT
   361  ALTFVVLVIS IAILYLRFGA QVLQDNFVAE LSTHYQNSAE FLSFYGLLNF YLYTLAFVYS
   421  PSKNALYESQ LKDNPAFSML NDSDDDVIYG SDYEEMPLQN GQAIRAKYKE ESDSD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TMEM181 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 9
Mean surface accessibility (rSASA): 0.31
Highest tissue expression: 52 nTPM

Expression across tissuesHPA

Tissue

salivary gland: 52 nTPM
stomach: 36 nTPM
pancreas: 33 nTPM
small intestine: 28 nTPM
cervix: 27 nTPM
rectum: 25 nTPM

Single-cell type

sertoli cells: 390 nCPM
pancreatic acinar cells: 260 nCPM
salivary acinar cells: 254 nCPM
nk-cells: 202 nCPM
foveolar cells: 202 nCPM
gonadotrophs: 193 nCPM

Immune cell

basophil: 6.1 nTPM
eosinophil: 3.1 nTPM
gdT-cell: 2.4 nTPM
NK-cell: 2.1 nTPM
non-classical monocyte: 2.1 nTPM
memory CD8 T-cell: 1.9 nTPM

Brain region

hypothalamus: 45 nTPM
cerebral cortex: 35 nTPM
hippocampal formation: 34 nTPM
basal ganglia: 33 nTPM
midbrain: 31 nTPM
white matter: 30 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.52
gnomAD pLI: 0.01
gnomAD missense Z: 0.02
DepMap mean gene effect: 0.02
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

toxic substance binding

Cellular components

membrane

Protein domainsUniProt · Pfam · InterPro

Wntless-like, transmembrane domain
Wntless-like, transmembrane domain
Transmembrane protein 181
TMEM181, GOLD domain
TMEM181, GOLD domain

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TMEM181 as an antibody target. Whether an autoantibody or antibody against TMEM181 could matter depends on whether native TMEM181 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TMEM181 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TMEM181 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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