Seroatlas · Human Serome Atlas

TMEM176B

Transmembrane protein 176B

Also known as: LR8, MS4B2, T176B_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q3YBM2
Gene: TMEM176B
Ensembl: ENSG00000106565
Chromosome: 7
Canonical length: 270 aa
Protein class: Predicted membrane proteins, Transporters
Subcellular location: Nucleoplasm,Golgi apparatus,Plasma membrane

OverviewNCBI Gene

Predicted to be involved in negative regulation of dendritic cell differentiation. Predicted to be located in nuclear membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

270 residues, UniProt reviewed canonical sequence.

>Q3YBM2|TMEM176B
     1  MTQNTVIVNG VAMASRPSQP THVNVHIHQE SALTQLLKAG GSLKKFLFHP GDTVPSTARI
    61  GYEQLALGVT QILLGVVSCV LGVCLSLGPW TVLSASGCAF WAGSVVIAAG AGAIVHEKHP
   121  GKLAGYISSL LTLAGFATAM AAVVLCVNSF IWQTEPFLYI DTVCDRSDPV FPTTGYRWMR
   181  RSQENQWQKE ECRAYMQMLR KLFTAIRALF LAVCVLKVIV SLVSLGVGLR NLCGQSSQPL
   241  NEEGSEKRLL GENSVPPSPS REQTSTAIVL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TMEM176B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 4
Mean surface accessibility (rSASA): 0.45
Highest tissue expression: 1,555 nTPM

Expression across tissuesHPA

Tissue

liver: 1,555 nTPM
kidney: 333 nTPM
small intestine: 278 nTPM
colon: 236 nTPM
rectum: 230 nTPM
heart muscle: 200 nTPM

Single-cell type

hepatocytes: 1,286 nCPM
enterocytes: 900 nCPM
epididymal efferent duct absorptive cells: 514 nCPM
colonocytes: 400 nCPM
schwann cells: 376 nCPM
granulosa cells: 324 nCPM

Immune cell

classical monocyte: 866 nTPM
intermediate monocyte: 587 nTPM
total PBMC: 499 nTPM
non-classical monocyte: 310 nTPM
myeloid DC: 164 nTPM
eosinophil: 51 nTPM

Brain region

white matter: 85 nTPM
medulla oblongata: 78 nTPM
spinal cord: 68 nTPM
midbrain: 58 nTPM
hypothalamus: 54 nTPM
pons: 53 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.75
gnomAD pLI: 0
gnomAD missense Z: -0.23
DepMap mean gene effect: -0.01
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

nuclear membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TMEM176B as an antibody target. Whether an autoantibody or antibody against TMEM176B could matter depends on whether native TMEM176B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TMEM176B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TMEM176B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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