Seroatlas · Human Serome Atlas

TMEM171

Transmembrane protein 171

Also known as: PRP2, TM171_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8WVE6
Gene: TMEM171
Ensembl: ENSG00000157111
Chromosome: 5
Canonical length: 324 aa
Protein class: Predicted membrane proteins

OverviewNCBI Gene

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

324 residues, UniProt reviewed canonical sequence.

>Q8WVE6|TMEM171
     1  MSPAAAAEPD GDQQDRHVSK LIFCFFVFGA VLLCVGVLLS IFGFQACQYK PLPDCPMVLK
    61  VAGPACAVVG LGAVILARSR AQLQLRAGLQ RGQQMDPDRA FICGESRQFA QCLIFGFLFL
   121  TSGMLISVLG IWVPGCGSNW AQEPLNETDT GDSEPRMCGF LSLQIMGPLI VLVGLCFFVV
   181  AHVKKRNTLN AGQDASEREE GQIQIMEPVQ VTVGDSVIIF PPPPPPYFPE SSASAVAESP
   241  GTNSLLPNEN PPSYYSIFNY GRTPTSEGAA SERDCESIYT ISGTNSSSEA SHTPHLPSEL
   301  PPRYEEKENA AATFLPLSSE PSPP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TMEM171 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 4
Mean surface accessibility (rSASA): 0.52
Highest tissue expression: 33 nTPM

Expression across tissuesHPA

Tissue

colon: 33 nTPM
rectum: 31 nTPM
thyroid gland: 29 nTPM
stomach: 26 nTPM
duodenum: 26 nTPM
small intestine: 19 nTPM

Single-cell type

parietal cells: 191 nCPM
colonocytes: 116 nCPM
breast lactating cells: 103 nCPM
esophageal apical cells: 75 nCPM
enteric transient amplifying cells: 63 nCPM
enteric stem cells: 52 nCPM

Immune cell

MAIT T-cell: 24 nTPM
memory CD8 T-cell: 8.2 nTPM
gdT-cell: 1.6 nTPM
memory CD4 T-cell: 0.9 nTPM
naive CD8 T-cell: 0.9 nTPM
total PBMC: 0.8 nTPM

Brain region

white matter: 5.8 nTPM
basal ganglia: 5.2 nTPM
cerebral cortex: 4 nTPM
thalamus: 4 nTPM
midbrain: 3.8 nTPM
hypothalamus: 3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.87
gnomAD pLI: 0
gnomAD missense Z: -0.17
DepMap mean gene effect: 0.02
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

membrane

Protein domainsUniProt · Pfam · InterPro

Transmembrane protein family 171
Transmembrane protein family 171

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TMEM171 as an antibody target. Whether an autoantibody or antibody against TMEM171 could matter depends on whether native TMEM171 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TMEM171 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TMEM171 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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