Seroatlas · Human Serome Atlas

TMEM170A

Transmembrane protein 170A

Also known as: FLJ37611, T170A_HUMAN, TMEM170

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8WVE7
Gene: TMEM170A
Ensembl: ENSG00000166822
Chromosome: 16
Canonical length: 144 aa
Protein class: Predicted membrane proteins, Transporters

OverviewNCBI Gene

Involved in endoplasmic reticulum tubular network organization; nuclear envelope organization; and nuclear pore complex assembly. Located in endoplasmic reticulum membrane and nuclear envelope. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

144 residues, UniProt reviewed canonical sequence.

>Q8WVE7|TMEM170A
     1  MEREGSGGSG GSAGLLQQIL SLKVVPRVGN GTLCPNSTSL CSFPEMWYGV FLWALVSSLF
    61  FHVPAGLLAL FTLRHHKYGR FMSVSILLMG IVGPITAGIL TSAAIAGVYR AAGKEMIPFE
   121  ALTLGTGQTF CVLVVSFLRI LATL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TMEM170A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 3
Mean surface accessibility (rSASA): 0.4
Highest tissue expression: 34 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 34 nTPM
spinal cord: 17 nTPM
testis: 16 nTPM
duodenum: 13 nTPM
retina: 13 nTPM
small intestine: 13 nTPM

Single-cell type

late primary spermatocytes: 19 nCPM
early spermatids: 9.4 nCPM
late spermatids: 3.5 nCPM
cholangiocytes: 2 nCPM
mucous neck cells: 2 nCPM
conjunctival goblet cells: 1.9 nCPM

Immune cell

eosinophil: 38 nTPM
MAIT T-cell: 37 nTPM
neutrophil: 33 nTPM
memory CD8 T-cell: 32 nTPM
naive CD4 T-cell: 31 nTPM
naive B-cell: 29 nTPM

Brain region

white matter: 47 nTPM
medulla oblongata: 36 nTPM
midbrain: 35 nTPM
basal ganglia: 34 nTPM
hypothalamus: 33 nTPM
spinal cord: 33 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.93
gnomAD pLI: 0
gnomAD missense Z: -0.5
DepMap mean gene effect: -0.02
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TMEM170A in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

RTN4

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TMEM170A as an antibody target. Whether an autoantibody or antibody against TMEM170A could matter depends on whether native TMEM170A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TMEM170A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TMEM170A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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