Seroatlas · Human Serome Atlas

TMEM168

Transmembrane protein 168

Also known as: DKFZp564C012, FLJ13576, TM168_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9H0V1
Gene
TMEM168
Ensembl
ENSG00000146802
Chromosome
7
Canonical length
697 aa
Protein class
Predicted intracellular proteins, Predicted membrane proteins, Transporters
Subcellular location
Golgi apparatus,Cytosol

OverviewNCBI Gene

Enables sodium channel regulator activity. Predicted to act upstream of or within regulation of ubiquitin-dependent protein catabolic process and regulation of voltage-gated sodium channel activity. Located in nuclear membrane and transport vesicle. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

697 residues, UniProt reviewed canonical sequence.

>Q9H0V1|TMEM168
     1  MCKSLRYCFS HCLYLAMTRL EEVNREVNMH SSVRYLGYLA RINLLVAICL GLYVRWEKTA
    61  NSLILVIFIL GLFVLGIASI LYYYFSMEAA SLSLSNLWFG FLLGLLCFLD NSSFKNDVKE
   121  ESTKYLLLTS IVLRILCSLV ERISGYVRHR PTLLTTVEFL ELVGFAIAST TMLVEKSLSV
   181  ILLVVALAML IIDLRMKSFL AIPNLVIFAV LLFFSSLETP KNPIAFACFF ICLITDPFLD
   241  IYFSGLSVTE RWKPFLYRGR ICRRLSVVFA GMIELTFFIL SAFKLRDTHL WYFVIPGFSI
   301  FGIFWMICHI IFLLTLWGFH TKLNDCHKVY FTHRTDYNSL DRIMASKGMR HFCLISEQLV
   361  FFSLLATAIL GAVSWQPTNG IFLSMFLIVL PLESMAHGLF HELGNCLGGT SVGYAIVIPT
   421  NFCSPDGQPT LLPPEHVQEL NLRSTGMLNA IQRFFAYHMI ETYGCDYSTS GLSFDTLHSK
   481  LKAFLELRTV DGPRHDTYIL YYSGHTHGTG EWALAGGDTL RLDTLIEWWR EKNGSFCSRL
   541  IIVLDSENST PWVKEVRKIN DQYIAVQGAE LIKTVDIEEA DPPQLGDFTK DWVEYNCNSS
   601  NNICWTEKGR TVKAVYGVSK RWSDYTLHLP TGSDVAKHWM LHFPRITYPL VHLANWLCGL
   661  NLFWICKTCF RCLKRLKMSW FLPTVLDTGQ GFKLVKS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TMEM168 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
11
Mean surface accessibility (rSASA)
0.26
Highest tissue expression
27 nTPM

Expression across tissuesHPA

Tissue

  • parathyroid gland: 27 nTPM
  • skin: 25 nTPM
  • rectum: 23 nTPM
  • colon: 21 nTPM
  • salivary gland: 19 nTPM
  • retina: 19 nTPM

Single-cell type

  • myonuclei: 151 nCPM
  • cytotrophoblasts: 121 nCPM
  • microglia: 113 nCPM
  • choroid plexus epithelial cells: 110 nCPM
  • cardiomyocytes: 106 nCPM
  • breast lactating cells: 106 nCPM

Immune cell

  • basophil: 21 nTPM
  • naive CD4 T-cell: 19 nTPM
  • myeloid DC: 16 nTPM
  • classical monocyte: 15 nTPM
  • MAIT T-cell: 14 nTPM
  • NK-cell: 14 nTPM

Brain region

  • white matter: 21 nTPM
  • choroid plexus: 21 nTPM
  • medulla oblongata: 18 nTPM
  • spinal cord: 17 nTPM
  • cerebellum: 17 nTPM
  • basal ganglia: 16 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.65
gnomAD pLI
0
gnomAD missense Z
0.89
DepMap mean gene effect
0.14
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Transmembrane protein 168

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TMEM168 as an antibody target. Whether an autoantibody or antibody against TMEM168 could matter depends on whether native TMEM168 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TMEM168 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TMEM168 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TMEM168. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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