Seroatlas · Human Serome Atlas

TMEM167B

Protein kish-B

Also known as: AD-020, C1orf119, FLJ90710, KISHB_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9NRX6
Gene
TMEM167B
Ensembl
ENSG00000215717
Chromosome
1
Canonical length
74 aa
Protein class
Predicted intracellular proteins, Predicted membrane proteins

OverviewNCBI Gene

Involved in constitutive secretory pathway. Located in Golgi apparatus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

74 residues, UniProt reviewed canonical sequence.

>Q9NRX6|TMEM167B
     1  MTNVYSLDGI LVFGLLFVCT CAYFKKVPRL KTWLLSEKKG VWGVFYKAAV IGTRLHAAVA
    61  IACVVMAFYV LFIK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TMEM167B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.48
Highest tissue expression
51 nTPM

Expression across tissuesHPA

Tissue

  • bone marrow: 51 nTPM
  • parathyroid gland: 42 nTPM
  • thyroid gland: 39 nTPM
  • prostate: 35 nTPM
  • heart muscle: 34 nTPM
  • adrenal gland: 34 nTPM

Single-cell type

  • neutrophils: 133 nCPM
  • esophageal apical cells: 130 nCPM
  • syncytiotrophoblasts: 87 nCPM
  • extravillous trophoblasts: 58 nCPM
  • esophageal suprabasal cells: 57 nCPM
  • kupffer cells: 50 nCPM

Immune cell

  • neutrophil: 46 nTPM
  • basophil: 38 nTPM
  • eosinophil: 36 nTPM
  • non-classical monocyte: 31 nTPM
  • intermediate monocyte: 24 nTPM
  • classical monocyte: 21 nTPM

Brain region

  • white matter: 28 nTPM
  • spinal cord: 25 nTPM
  • hypothalamus: 24 nTPM
  • thalamus: 24 nTPM
  • midbrain: 23 nTPM
  • basal ganglia: 23 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.79
gnomAD pLI
0.68
gnomAD missense Z
0.81
DepMap mean gene effect
-0.05
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TMEM167B as an antibody target. Whether an autoantibody or antibody against TMEM167B could matter depends on whether native TMEM167B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TMEM167B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TMEM167B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TMEM167B. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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