Seroatlas · Human Serome Atlas

TMEM167A

Protein kish-A

Also known as: FLJ30508, KISHA_HUMAN, MGC23909, TMEM167

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8TBQ9
Gene: TMEM167A
Ensembl: ENSG00000174695
Chromosome: 5
Canonical length: 72 aa
Protein class: Predicted membrane proteins
Subcellular location: Vesicles

OverviewNCBI Gene

Involved in constitutive secretory pathway. Located in Golgi apparatus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

72 residues, UniProt reviewed canonical sequence.

>Q8TBQ9|TMEM167A
     1  MSAIFNFQSL LTVILLLICT CAYIRSLAPS LLDRNKTGLL GIFWKCARIG ERKSPYVAVC
    61  CIVMAFSILF IQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TMEM167A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.45
Highest tissue expression: 46 nTPM

Expression across tissuesHPA

Tissue

adrenal gland: 46 nTPM
placenta: 33 nTPM
retina: 32 nTPM
kidney: 32 nTPM
midbrain: 32 nTPM
cerebral cortex: 31 nTPM

Single-cell type

extravillous trophoblasts: 429 nCPM
esophageal apical cells: 352 nCPM
megakaryocytes: 235 nCPM
esophageal suprabasal cells: 229 nCPM
syncytiotrophoblasts: 214 nCPM
decidual stromal cells: 200 nCPM

Immune cell

basophil: 26 nTPM
non-classical monocyte: 24 nTPM
classical monocyte: 22 nTPM
intermediate monocyte: 20 nTPM
neutrophil: 12 nTPM
myeloid DC: 12 nTPM

Brain region

hypothalamus: 61 nTPM
thalamus: 53 nTPM
midbrain: 52 nTPM
cerebellum: 50 nTPM
pons: 50 nTPM
medulla oblongata: 47 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about TMEM167A.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 21 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Microcephaly, epilepsy, and diabetes syndrome

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.79
gnomAD pLI: 0
gnomAD missense Z: 0.41
DepMap mean gene effect: -0.33
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TMEM167A as an antibody target. Whether an autoantibody or antibody against TMEM167A could matter depends on whether native TMEM167A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TMEM167A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TMEM167A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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