Seroatlas · Human Serome Atlas

TMEM161B

Transmembrane protein 161B

Also known as: MGC33214, T161B_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8NDZ6
Gene: TMEM161B
Ensembl: ENSG00000164180
Chromosome: 5
Canonical length: 487 aa
Protein class: Predicted membrane proteins

OverviewNCBI Gene

Predicted to enable nucleic acid binding activity. Predicted to be involved in regulation of cardiac muscle cell action potential and regulation of heart rate. Predicted to be located in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

487 residues, UniProt reviewed canonical sequence.

>Q8NDZ6|TMEM161B
     1  MGVIGIQLVV TMVMASVMQK IIPHYSLARW LLCNGSLRWY QHPTEEELRI LAGKQQKGKT
    61  KKDRKYNGHI ESKPLTIPKD IDLHLETKSV TEVDTLALHY FPEYQWLVDF TVAATVVYLV
   121  TEVYYNFMKP TQEMNISLVW CLLVLSFAIK VLFSLTTHYF KVEDGGERSV CVTFGFFFFV
   181  KAMAVLIVTE NYLEFGLETG FTNFSDSAMQ FLEKQGLESQ SPVSKLTFKF FLAIFCSFIG
   241  AFLTFPGLRL AQMHLDALNL ATEKITQTLL HINFLAPLFM VLLWVKPITK DYIMNPPLGK
   301  ESIPLMTEAT FDTLRLWLII LLCALRLAMM RSHLQAYLNL AQKCVDQMKK EAGRISTVEL
   361  QKMVARVFYY LCVIALQYVA PLVMLLHTTL LLKTLGNHSW GIYPESISTL PVDNSLLSNS
   421  VYSELPSAEG KMKVTVTQIT VALSSLKNIF TPLLFRGLLS FLTWWIAACL FSTSLFGLFY
   481  HQYLTVA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TMEM161B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 8
Mean surface accessibility (rSASA): 0.31
Highest tissue expression: 38 nTPM

Expression across tissuesHPA

Tissue

parathyroid gland: 38 nTPM
thyroid gland: 31 nTPM
stomach: 24 nTPM
epididymis: 22 nTPM
pancreas: 22 nTPM
breast: 20 nTPM

Single-cell type

parietal cells: 203 nCPM
choroid plexus epithelial cells: 92 nCPM
distal convoluted tubule cells: 79 nCPM
lactotrophs: 72 nCPM
thyrotrophs: 71 nCPM
cardiomyocytes: 69 nCPM

Immune cell

MAIT T-cell: 3 nTPM
NK-cell: 3 nTPM
gdT-cell: 2.9 nTPM
intermediate monocyte: 2.8 nTPM
plasmacytoid DC: 2.6 nTPM
naive CD4 T-cell: 2.5 nTPM

Brain region

cerebellum: 27 nTPM
cerebral cortex: 25 nTPM
white matter: 24 nTPM
basal ganglia: 23 nTPM
hippocampal formation: 21 nTPM
hypothalamus: 20 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about TMEM161B.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 57 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Polymicrogyria

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.72
gnomAD pLI: 0
gnomAD missense Z: 1.19
DepMap mean gene effect: -0.04
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

plasma membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TMEM161B as an antibody target. Whether an autoantibody or antibody against TMEM161B could matter depends on whether native TMEM161B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TMEM161B is annotated at the cell surface, where native TMEM161B is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label TMEM161B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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