TMEM158
Transmembrane protein 158
Also known as: p40BBp, RIS1, TM158_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q8WZ71
- Gene
- TMEM158
- Ensembl
- ENSG00000249992
- Chromosome
- 3
- Canonical length
- 300 aa
- Protein class
- Predicted membrane proteins
OverviewNCBI Gene
Constitutive activation of the Ras pathway triggers an irreversible proliferation arrest reminiscent of replicative senescence. Transcription of this gene is upregulated in response to activation of the Ras pathway, but not under other conditions that induce senescence. The encoded protein is similar to a rat cell surface receptor proposed to function in a neuronal survival pathway. An allelic polymorphism in this gene results in both functional and non-functional (frameshifted) alleles; the reference genome represents the functional allele. [provided by RefSeq, Jul 2015]
Canonical amino-acid sequenceUniProt
300 residues, UniProt reviewed canonical sequence.
>Q8WZ71|TMEM158
1 MLPLLAALLA AACPLPPVRG GAADAPGLLG VPSNASVNAS SADEPIAPRL LASAAPGPPE
61 RPGPEEAAAA AAPCNISVQR QMLSSLLVRW GRPRGFQCDL LLFSTNAHGR AFFAAAFHRV
121 GPPLLIEHLG LAAGGAQQDL RLCVGCGWVR GRRTGRLRPA AAPSAAAATA GAPTALPAYP
181 AAEPPGPLWL QGEPLHFCCL DFSLEELQGE PGWRLNRKPI ESTLVACFMT LVIVVWSVAA
241 LIWPVPIIAG FLPNGMEQRR TTASTTAATP AAVPAGTTAA AAAAAAAAAA AAVTSGVATKLocalizationUniProt · AlphaFold · HPA
Whether an antibody against TMEM158 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Unknown
- Secreted
- No
- Transmembrane segments
- 2
- Mean surface accessibility (rSASA)
- 0.56
- Highest tissue expression
- 83 nTPM
Expression across tissuesHPA
Tissue
- basal ganglia: 83 nTPM
- endometrium: 60 nTPM
- amygdala: 25 nTPM
- hypothalamus: 23 nTPM
- seminal vesicle: 21 nTPM
- hippocampal formation: 20 nTPM
Single-cell type
- platelets: 228 nCPM
- müller glia: 94 nCPM
- other brain neurons: 59 nCPM
- ependymal cells: 58 nCPM
- endometrial stromal cells: 47 nCPM
- brain inhibitory neurons: 46 nCPM
Immune cell
- total PBMC: 0.1 nTPM
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
Brain region
- basal ganglia: 57 nTPM
- hypothalamus: 44 nTPM
- midbrain: 36 nTPM
- cerebral cortex: 34 nTPM
- hippocampal formation: 33 nTPM
- amygdala: 28 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.74
- gnomAD pLI
- 0.15
- gnomAD missense Z
- 1.09
- DepMap mean gene effect
- 0.08
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
- Transmembrane protein 158
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads TMEM158 as an antibody target. Whether an autoantibody or antibody against TMEM158 could matter depends on whether native TMEM158 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
TMEM158 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label TMEM158 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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