Seroatlas · Human Serome Atlas

TMEM156

Transmembrane protein 156

Also known as: FLJ23235, TM156_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8N614
Gene: TMEM156
Ensembl: ENSG00000121895
Chromosome: 4
Canonical length: 296 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins

OverviewNCBI Gene

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

296 residues, UniProt reviewed canonical sequence.

>Q8N614|TMEM156
     1  MTKTALLKLF VAIVITFILI LPEYFKTPKE RTLELSCLEV CLQSNFTYSL SSLNFSFVTF
    61  LQPVRETQII MRIFLNPSNF RNFTRTCQDI TGEFKMCSSC LVCESKGNMD FISQEQTSKV
   121  LIRRGSMEVK ANDFHSPCQH FNFSVAPLVD HLEEYNTTCH LKNHTGRSTI MEDEPSKEKS
   181  INYTCRIMEY PNDCIHISLH LEMDIKNITC SMKITWYILV LLVFIFLIIL TIRKILEGQR
   241  RVQKWQSHRD KPTSVLLRGS DSEKLRALNV QVLSAETTQR LPLDQVQEVL PPIPEL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TMEM156 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 2
Mean surface accessibility (rSASA): 0.56
Highest tissue expression: 25 nTPM

Expression across tissuesHPA

Tissue

tonsil: 25 nTPM
lymph node: 22 nTPM
spleen: 10 nTPM
appendix: 8.5 nTPM
small intestine: 4.8 nTPM
thymus: 4.8 nTPM

Single-cell type

microglia: 394 nCPM
b-cells: 337 nCPM
plasma cells: 271 nCPM
innate lymphoid cells: 140 nCPM
thymocytes: 101 nCPM
nk-cells: 94 nCPM

Immune cell

memory B-cell: 75 nTPM
naive B-cell: 60 nTPM
eosinophil: 49 nTPM
memory CD4 T-cell: 21 nTPM
basophil: 17 nTPM
T-reg: 15 nTPM

Brain region

white matter: 7.9 nTPM
medulla oblongata: 6.6 nTPM
pons: 6.3 nTPM
spinal cord: 5.6 nTPM
midbrain: 5.1 nTPM
cerebral cortex: 4.9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.66
gnomAD pLI: 0
gnomAD missense Z: -0.19
DepMap mean gene effect: 0.05
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

membrane

Protein domainsUniProt · Pfam · InterPro

TMEM156 protein
TMEM156 protein family

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TMEM156 as an antibody target. Whether an autoantibody or antibody against TMEM156 could matter depends on whether native TMEM156 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TMEM156 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TMEM156 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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