TMEM154
Transmembrane protein 154
Also known as: FLJ32028, TM154_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q6P9G4
- Gene
- TMEM154
- Ensembl
- ENSG00000170006
- Chromosome
- 4
- Canonical length
- 183 aa
- Protein class
- Predicted intracellular proteins, Predicted membrane proteins
- Subcellular location
- Nucleoplasm,Nuclear membrane
OverviewNCBI Gene
Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
183 residues, UniProt reviewed canonical sequence.
>Q6P9G4|TMEM154
1 MQAPRAALVF ALVIALVPVG RGNYEELENS GDTTVESERP NKVTIPSTFA AVTIKETLNA
61 NINSTNFAPD ENQLEFILMV LIPLILLVLL LLSVVFLATY YKRKRTKQEP SSQGSQSALQ
121 TYELGSENVK VPIFEEDTPS VMEIEMEELD KWMNSMNRNA DFECLPTLKE EKESNHNPSD
181 SESLocalizationUniProt · AlphaFold · HPA
Whether an antibody against TMEM154 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Unknown
- Secreted
- No
- Transmembrane segments
- 1
- Mean surface accessibility (rSASA)
- 0.63
- Highest tissue expression
- 46 nTPM
Expression across tissuesHPA
Tissue
- skin: 46 nTPM
- esophagus: 19 nTPM
- tonsil: 8.8 nTPM
- bone marrow: 8.3 nTPM
- spleen: 6.2 nTPM
- urinary bladder: 5.1 nTPM
Single-cell type
- esophageal apical cells: 1,271 nCPM
- neutrophils: 1,234 nCPM
- suprabasal keratinocytes: 560 nCPM
- esophageal suprabasal cells: 488 nCPM
- neutrophil progenitors: 395 nCPM
- urothelial cells: 265 nCPM
Immune cell
- basophil: 37 nTPM
- neutrophil: 36 nTPM
- eosinophil: 21 nTPM
- classical monocyte: 6 nTPM
- non-classical monocyte: 4.5 nTPM
- intermediate monocyte: 4.1 nTPM
Brain region
- white matter: 3.2 nTPM
- cerebellum: 2.7 nTPM
- medulla oblongata: 2.7 nTPM
- pons: 2.7 nTPM
- thalamus: 2.7 nTPM
- basal ganglia: 2.5 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.61
- gnomAD pLI
- 0
- gnomAD missense Z
- -0.88
- DepMap mean gene effect
- 0.08
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Cellular components
Protein domainsUniProt · Pfam · InterPro
- Transmembrane protein 154
- Transmembrane protein 154-like
- TMEM154 protein family
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads TMEM154 as an antibody target. Whether an autoantibody or antibody against TMEM154 could matter depends on whether native TMEM154 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
TMEM154 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label TMEM154 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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