Seroatlas · Human Serome Atlas

TMEM151B

Transmembrane protein 151B

Also known as: bA444E17.5, C6orf137, T151B_HUMAN, TMEM193

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8IW70
Gene: TMEM151B
Ensembl: ENSG00000178233
Chromosome: 6
Canonical length: 566 aa
Protein class: Predicted membrane proteins

OverviewNCBI Gene

Predicted to be active in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

566 residues, UniProt reviewed canonical sequence.

>Q8IW70|TMEM151B
     1  MSPPGSAAGE SAAGGGGGGG GPGVSEELTA AAAAAAADEG PAREEQRPIQ PSFTKSLCRE
    61  SHWKCLLLSL LMYGCLGAVA WCHVTTVTRL TFSSAYQGNS LMYHDSPCSN GYVYIPLAFL
   121  LMLYAVYLVE CWHCQARHEL QHRVDVSSVR ERVGRMQQAT PCIWWKAISY HYVRRTRQVT
   181  RYRNGDAYTT TQVYHERVNT HVAEAEFDYA RCGVRDVSKT LVGLEGAPAT RLRFTKCFSF
   241  ASVEAENAYL CQRARFFAEN EGLDDYMEAR EGMHLKNVDF REFMVAFPDP ARPPWYACSS
   301  AFWAAALLTL SWPLRVLAEY RTAYAHYHVE KLFGLEGPGS ASSAGGGLSP SDELLPPLTH
   361  RLPRVNTVDS TELEWHIRSN QQLVPSYSEA VLMDLAGLGT RCGGAGGGYA PSCRYGGVGG
   421  PGAAGVAPYR RSCEHCQRAV SSSSIFSRSA LSICASPRAG PGPGGGAGCG GSRFSLGRLY
   481  GSRRSCLWRS RSGSVNEASC PTEQTRLSSQ ASMGDDEDDD EEEAGPPPPY HDALYFPVLI
   541  VHRQEGCLGH SHRPLHRHGS CVETSL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TMEM151B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 2
Mean surface accessibility (rSASA): 0.49
Highest tissue expression: 135 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 135 nTPM
cerebral cortex: 73 nTPM
hippocampal formation: 47 nTPM
amygdala: 31 nTPM
hypothalamus: 21 nTPM
midbrain: 17 nTPM

Single-cell type

brain excitatory neurons: 3.5 nCPM
brain inhibitory neurons: 1.5 nCPM
other brain neurons: 1.1 nCPM
breast myoepithelial cells: 0.9 nCPM
lacrimal acinar cells: 0.9 nCPM
prostatic hillock cells: 0.6 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebral cortex: 165 nTPM
cerebellum: 152 nTPM
hippocampal formation: 126 nTPM
basal ganglia: 87 nTPM
white matter: 84 nTPM
thalamus: 81 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.64
gnomAD pLI: 0.14
gnomAD missense Z: 3.42
DepMap mean gene effect: -0.03
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TMEM151B as an antibody target. Whether an autoantibody or antibody against TMEM151B could matter depends on whether native TMEM151B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TMEM151B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TMEM151B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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