Seroatlas · Human Serome Atlas

TMEM151A

Transmembrane protein 151A

Also known as: MGC33486, T151A_HUMAN, TMEM151

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8N4L1
Gene
TMEM151A
Ensembl
ENSG00000179292
Chromosome
11
Canonical length
468 aa
Protein class
Predicted membrane proteins
Subcellular location
Nucleoli,Cytosol

OverviewNCBI Gene

Located in endoplasmic reticulum and membrane. Implicated in episodic kinesigenic dyskinesia 3. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

468 residues, UniProt reviewed canonical sequence.

>Q8N4L1|TMEM151A
     1  MPEDGAGDGG EVPALIPDGE PLREEQRPLK QSLGSSLCRE SHWKCLLLTL LIHACGAVVA
    61  WCRLATVPRL VLGPEAALAR GAGGPPPTYP ASPCSDGYLY IPLAFVSLLY LLYLAECWHC
   121  HVRSCQAPRT DAHTVLALIR RLQQAPPCVW WKATSYHYVR RTRQITRYRN GDAYTTTQVY
   181  HERADSRTAR GEFDYSAHGV RDVSKELVGL AEHAATRLRF TKCFSFGSAE AEASYLTQRA
   241  RFFSANEGLD DYLEAREGMH LKDVDFRESL MVFADPRSPP WYARAWVFWL VSAATLSWPL
   301  RVVAAYGTAH VHYQVEKLFG ASSPPPGAVP SGPPLSRVAT VDFTELEWHI CSNRQLVPSY
   361  SEAVVMGAGS GAYLRGCQRC RRSVSSNSLP PARPSGPRLP FSRSRLSLGA GGRATPGVFR
   421  SLSGGPLGRR GEDTEPLESP PCYEDALYFP VLIVHGDSGC QGDGQGAL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TMEM151A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
2
Mean surface accessibility (rSASA)
0.43
Highest tissue expression
134 nTPM

Expression across tissuesHPA

Tissue

  • spinal cord: 134 nTPM
  • hippocampal formation: 63 nTPM
  • midbrain: 59 nTPM
  • basal ganglia: 42 nTPM
  • cerebral cortex: 41 nTPM
  • hypothalamus: 40 nTPM

Single-cell type

  • oligodendrocytes: 89 nCPM
  • other brain neurons: 23 nCPM
  • brain inhibitory neurons: 20 nCPM
  • retinal pigment epithelial cells: 17 nCPM
  • brain excitatory neurons: 16 nCPM
  • mesothelial cells: 9.2 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • white matter: 227 nTPM
  • medulla oblongata: 183 nTPM
  • cerebellum: 155 nTPM
  • pons: 148 nTPM
  • thalamus: 147 nTPM
  • midbrain: 143 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about TMEM151A.

Disease | AllUniProt

Conditions TMEM151A is implicated in, by any mechanism.

  • Episodic kinesigenic dyskinesia 3 (EKD3) MIM:620245

Disease | GeneticClinVar

11 pathogenic / likely-pathogenic of 86 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Episodic kinesigenic dyskinesia 3
  • TMEM151A-related disorder

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.94
gnomAD pLI
0
gnomAD missense Z
2.67
DepMap mean gene effect
-0.04
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TMEM151A as an antibody target. Whether an autoantibody or antibody against TMEM151A could matter depends on whether native TMEM151A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TMEM151A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TMEM151A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TMEM151A. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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