TMEM150C
Transmembrane protein 150C
Also known as: FLJ12993, T150C_HUMAN, TTN3
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- B9EJG8
- Gene
- TMEM150C
- Ensembl
- ENSG00000249242
- Chromosome
- 4
- Canonical length
- 249 aa
- Protein class
- Predicted membrane proteins, Transporters
OverviewNCBI Gene
This gene encodes a transmembrane protein component of a mechanosensitve ion channel that is activated by mechanical stimuli in various cell types and confers slowly adapting, mechanically activated currents in dorsal root ganglion neurons. Mechanically activated ion channels are sensors that are critical for hearing, touch, pain, and blood pressure regulation. [provided by RefSeq, Jul 2017]
Canonical amino-acid sequenceUniProt
249 residues, UniProt reviewed canonical sequence.
>B9EJG8|TMEM150C
1 MDGKKCSVWM FLPLVFTLFT SAGLWIVYFI AVEDDKILPL NSAERKPGVK HAPYISIAGD
61 DPPASCVFSQ VMNMAAFLAL VVAVLRFIQL KPKVLNPWLN ISGLVALCLA SFGMTLLGNF
121 QLTNDEEIHN VGTSLTFGFG TLTCWIQAAL TLKVNIKNEG RRVGIPRVIL SASITLCVVL
181 YFILMAQSIH MYAARVQWGL VMCFLSYFGT FAVEFRHYRY EIVCSEYQEN FLSFSESLSE
241 ASEYQTDQVLocalizationUniProt · AlphaFold · HPA
Whether an antibody against TMEM150C can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Cell surface
- Secreted
- No
- Transmembrane segments
- 6
- Mean surface accessibility (rSASA)
- 0.3
- Highest tissue expression
- 127 nTPM
Expression across tissuesHPA
Tissue
- epididymis: 127 nTPM
- adrenal gland: 39 nTPM
- ovary: 29 nTPM
- breast: 21 nTPM
- cerebral cortex: 19 nTPM
- kidney: 16 nTPM
Single-cell type
- podocytes: 289 nCPM
- epididymal principal cells: 223 nCPM
- syncytiotrophoblasts: 205 nCPM
- cytotrophoblasts: 190 nCPM
- somatotrophs: 155 nCPM
- adrenal cortex cells: 136 nCPM
Immune cell
- basophil: 2.2 nTPM
- neutrophil: 1.3 nTPM
- memory B-cell: 1 nTPM
- naive B-cell: 1 nTPM
- eosinophil: 0.5 nTPM
- NK-cell: 0.5 nTPM
Brain region
- midbrain: 27 nTPM
- cerebral cortex: 26 nTPM
- hippocampal formation: 25 nTPM
- pons: 25 nTPM
- basal ganglia: 24 nTPM
- medulla oblongata: 20 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.87
- gnomAD pLI
- 0.01
- gnomAD missense Z
- 1.52
- DepMap mean gene effect
- -0.1
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads TMEM150C as an antibody target. Whether an autoantibody or antibody against TMEM150C could matter depends on whether native TMEM150C is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
TMEM150C is annotated at the cell surface, where native TMEM150C is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.
Annotation status
The present source text does not explicitly label TMEM150C as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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