Seroatlas · Human Serome Atlas

TMEM150B

Modulator of macroautophagy TMEM150B

Also known as: DRAM3, T150B_HUMAN, TMEM224, TTN2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A6NC51
Gene: TMEM150B
Ensembl: ENSG00000180061
Chromosome: 19
Canonical length: 233 aa
Protein class: Predicted membrane proteins, Transporters

OverviewNCBI Gene

This gene encodes a protein that belongs to the DRAM (damage-regulated autophagy modulator) family of membrane-spanning proteins. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

Canonical amino-acid sequenceUniProt

233 residues, UniProt reviewed canonical sequence.

>A6NC51|TMEM150B
     1  MWGYLSLMPV FLAVWAISGV WIVFAIAVTN RTVDLSKGFP YISICGSFPP QSCIFSQVLN
    61  MGAALAAWIC IVRYHQLRDW GVRRWPNQLI LWTGLLCALG TSVVGNFQEK NQRPTHLAGA
   121  FLAFILGNVY FWLQLLLWRL KRLPQPGAAW IGPLRLGLCS VCTILIVAMI VLHACSLRSV
   181  SAACEWVVAM LLFALFGLLA VDFSALESCT LCVQPWPSLS PPPASPISLP VQL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TMEM150B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 6
Mean surface accessibility (rSASA): 0.31
Highest tissue expression: 60 nTPM

Expression across tissuesHPA

Tissue

duodenum: 60 nTPM
small intestine: 54 nTPM
lung: 11 nTPM
colon: 9.6 nTPM
rectum: 6.8 nTPM
appendix: 5.5 nTPM

Single-cell type

enterocytes: 107 nCPM
proximal tubule cells: 28 nCPM
kupffer cells: 20 nCPM
colonocytes: 17 nCPM
monocytes: 17 nCPM
goblet cells: 13 nCPM

Immune cell

classical monocyte: 5.7 nTPM
basophil: 1.9 nTPM
intermediate monocyte: 1.1 nTPM
total PBMC: 0.8 nTPM
myeloid DC: 0.5 nTPM
non-classical monocyte: 0.3 nTPM

Brain region

thalamus: 6.4 nTPM
pons: 2.6 nTPM
medulla oblongata: 2 nTPM
choroid plexus: 1.8 nTPM
white matter: 1.8 nTPM
cerebral cortex: 1.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.72
gnomAD pLI: 0
gnomAD missense Z: -0.27
DepMap mean gene effect: 0.13
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

autophagy

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TMEM150B as an antibody target. Whether an autoantibody or antibody against TMEM150B could matter depends on whether native TMEM150B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TMEM150B is annotated at the cell surface, where native TMEM150B is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label TMEM150B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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