Seroatlas · Human Serome Atlas

TMEM150A

Transmembrane protein 150A

Also known as: FLJ90024, T150A_HUMAN, TM6P1, TMEM150, TTN1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q86TG1
Gene: TMEM150A
Ensembl: ENSG00000168890
Chromosome: 2
Canonical length: 271 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins, Transporters

OverviewNCBI Gene

Involved in phosphatidylinositol phosphate biosynthetic process and protein localization to plasma membrane. Located in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

271 residues, UniProt reviewed canonical sequence.

>Q86TG1|TMEM150A
     1  MTAWILLPVS LSAFSITGIW TVYAMAVMNH HVCPVENWSY NESCPPDPAE QGGPKTCCTL
    61  DDVPLISKCG SYPPESCLFS LIGNMGAFMV ALICLLRYGQ LLEQSRHSWV NTTALITGCT
   121  NAAGLLVVGN FQVDHARSLH YVGAGVAFPA GLLFVCLHCA LSYQGATAPL DLAVAYLRSV
   181  LAVIAFITLV LSGVFFVHES SQLQHGAALC EWVCVIDILI FYGTFSYEFG AVSSDTLVAA
   241  LQPTPGRACK SSGSSSTSTH LNCAPESIAM I

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TMEM150A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 6
Mean surface accessibility (rSASA): 0.3
Highest tissue expression: 49 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 49 nTPM
liver: 36 nTPM
pancreas: 35 nTPM
kidney: 31 nTPM
tongue: 25 nTPM
testis: 23 nTPM

Single-cell type

early spermatids: 192 nCPM
cytotrophoblasts: 173 nCPM
syncytiotrophoblasts: 151 nCPM
late spermatids: 90 nCPM
migrating cytotrophoblasts: 61 nCPM
epididymal efferent duct absorptive cells: 43 nCPM

Immune cell

intermediate monocyte: 18 nTPM
classical monocyte: 15 nTPM
non-classical monocyte: 15 nTPM
myeloid DC: 13 nTPM
NK-cell: 8.4 nTPM
naive B-cell: 8.2 nTPM

Brain region

medulla oblongata: 11 nTPM
thalamus: 10 nTPM
choroid plexus: 9.4 nTPM
pons: 9.1 nTPM
basal ganglia: 8.7 nTPM
midbrain: 8.6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.77
gnomAD pLI: 0.02
gnomAD missense Z: 1.42
DepMap mean gene effect: 0.01
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

plasma membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TMEM150A in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

PI4KA

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TMEM150A as an antibody target. Whether an autoantibody or antibody against TMEM150A could matter depends on whether native TMEM150A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TMEM150A is annotated at the cell surface, where native TMEM150A is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label TMEM150A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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