Seroatlas · Human Serome Atlas

TMEM14EP

Transmembrane protein 14EP

Also known as: TM14E_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6UXP3
Gene: TMEM14EP
Canonical length: 125 aa

OverviewNCBI Gene

No narrative summary is available for TMEM14EP in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

125 residues, UniProt reviewed canonical sequence.

>Q6UXP3|TMEM14EP
     1  MQMDPGPQVP LYWLGFVYAA LAALGGISGY AKVGSVQSPS AGFFFSELAG LDASQPSRNP
    61  KEHLSSPVYI WDLARYYANK ILTLWNIYAC GFSCRCLLIV SKLGSMYGEQ ILSVVAMSQL
   121  GLMKN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TMEM14EP can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 2
Mean surface accessibility (rSASA): 0.51

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

heme biosynthetic process

Cellular components

mitochondrial membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TMEM14EP as an antibody target. Whether an autoantibody or antibody against TMEM14EP could matter depends on whether native TMEM14EP is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TMEM14EP is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TMEM14EP as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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