Seroatlas · Human Serome Atlas

TMEM14DP

Transmembrane protein 14DP

Also known as: TM14D_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A8MWL7
Gene: TMEM14DP
Canonical length: 114 aa

OverviewNCBI Gene

No narrative summary is available for TMEM14DP in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

114 residues, UniProt reviewed canonical sequence.

>A8MWL7|TMEM14DP
     1  MEKPLFPLVP LHWFGFGYTA LVVSGGIVGY VKTGRAPSLA AGLLFGSLAG VGAYQLYQDP
    61  RNVWDFLAAT SVTFVGIMGM RSYYYGKFMP VGLIAGASLL MAAKVGVRML MTSD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TMEM14DP can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 4
Mean surface accessibility (rSASA): 0.55

OntologyGO

Biological processes

heme biosynthetic process

Cellular components

mitochondrial membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TMEM14DP as an antibody target. Whether an autoantibody or antibody against TMEM14DP could matter depends on whether native TMEM14DP is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TMEM14DP is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TMEM14DP as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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