TMEM14C
Transmembrane protein 14C
Also known as: bA421M1.6, C6orf53, HSPC194, NET26, TM14C_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q9P0S9
- Gene
- TMEM14C
- Ensembl
- ENSG00000111843
- Chromosome
- 6
- Canonical length
- 112 aa
- Protein class
- Predicted membrane proteins, Transporters
OverviewNCBI Gene
Predicted to be involved in regulation of heme biosynthetic process. Predicted to act upstream of or within erythrocyte differentiation; mitochondrial transport; and nitrogen compound transport. Located in mitochondrion. [provided by Alliance of Genome Resources, Apr 2025]
Canonical amino-acid sequenceUniProt
112 residues, UniProt reviewed canonical sequence.
>Q9P0S9|TMEM14C
1 MQDTGSVVPL HWFGFGYAAL VASGGIIGYV KAGSVPSLAA GLLFGSLAGL GAYQLSQDPR
61 NVWVFLATSG TLAGIMGMRF YHSGKFMPAG LIAGASLLMV AKVGVSMFNR PHLocalizationUniProt · AlphaFold · HPA
Whether an antibody against TMEM14C can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Other membrane
- Secreted
- No
- Transmembrane segments
- 4
- Mean surface accessibility (rSASA)
- 0.55
- Highest tissue expression
- 143 nTPM
Expression across tissuesHPA
Tissue
- adrenal gland: 143 nTPM
- skeletal muscle: 138 nTPM
- heart muscle: 129 nTPM
- blood vessel: 128 nTPM
- kidney: 127 nTPM
- adipose tissue: 110 nTPM
Single-cell type
- erythrocyte progenitors: 110 nCPM
- megakaryocyte-erythroid progenitors: 73 nCPM
- endometrial secretory cells: 64 nCPM
- conjunctival goblet cells: 57 nCPM
- ocular epithelial cells: 56 nCPM
- fallopian secretory cells: 53 nCPM
Immune cell
- myeloid DC: 71 nTPM
- eosinophil: 68 nTPM
- plasmacytoid DC: 66 nTPM
- basophil: 48 nTPM
- intermediate monocyte: 39 nTPM
- classical monocyte: 39 nTPM
Brain region
- choroid plexus: 45 nTPM
- white matter: 31 nTPM
- hypothalamus: 28 nTPM
- cerebellum: 28 nTPM
- spinal cord: 27 nTPM
- thalamus: 27 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.43
- gnomAD pLI
- 0.01
- gnomAD missense Z
- 0.17
- DepMap mean gene effect
- 0.09
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads TMEM14C as an antibody target. Whether an autoantibody or antibody against TMEM14C could matter depends on whether native TMEM14C is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
TMEM14C is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label TMEM14C as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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