TMEM14A
Transmembrane protein 14A
Also known as: C6orf73, PTD011, TM14A_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q9Y6G1
- Gene
- TMEM14A
- Ensembl
- ENSG00000096092
- Chromosome
- 6
- Canonical length
- 99 aa
- Protein class
- Predicted membrane proteins, Transporters
- Subcellular location
- Nucleoplasm,Endoplasmic reticulum
OverviewNCBI Gene
Involved in negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway. Located in endoplasmic reticulum membrane and mitochondrial membrane. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
99 residues, UniProt reviewed canonical sequence.
>Q9Y6G1|TMEM14A
1 MDLIGFGYAA LVTFGSIFGY KRRGGVPSLI AGLFVGCLAG YGAYRVSNDK RDVKVSLFTA
61 FFLATIMGVR FKRSKKIMPA GLVAGLSLMM ILRLVLLLLLocalizationUniProt · AlphaFold · HPA
Whether an antibody against TMEM14A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Other membrane
- Secreted
- No
- Transmembrane segments
- 3
- Mean surface accessibility (rSASA)
- 0.57
- Highest tissue expression
- 117 nTPM
Expression across tissuesHPA
Tissue
- choroid plexus: 117 nTPM
- liver: 99 nTPM
- hypothalamus: 79 nTPM
- cerebral cortex: 78 nTPM
- spinal cord: 63 nTPM
- basal ganglia: 63 nTPM
Single-cell type
- esophageal suprabasal cells: 266 nCPM
- esophageal basal cells: 261 nCPM
- extravillous trophoblasts: 212 nCPM
- oocytes: 198 nCPM
- gastric progenitor cells: 172 nCPM
- hepatocytes: 166 nCPM
Immune cell
- T-reg: 67 nTPM
- memory B-cell: 55 nTPM
- memory CD4 T-cell: 49 nTPM
- memory CD8 T-cell: 40 nTPM
- naive CD8 T-cell: 40 nTPM
- gdT-cell: 39 nTPM
Brain region
- choroid plexus: 82 nTPM
- hypothalamus: 61 nTPM
- pons: 45 nTPM
- white matter: 45 nTPM
- medulla oblongata: 44 nTPM
- cerebral cortex: 44 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.41
- gnomAD pLI
- 0.02
- gnomAD missense Z
- 0.63
- DepMap mean gene effect
- 0.16
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
- apoptotic process
- negative regulation of apoptotic process
- negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads TMEM14A as an antibody target. Whether an autoantibody or antibody against TMEM14A could matter depends on whether native TMEM14A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
TMEM14A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label TMEM14A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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