Seroatlas · Human Serome Atlas

TMEM145

Transmembrane protein 145

Also known as: FLJ90805, TM145_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8NBT3
Gene: TMEM145
Ensembl: ENSG00000167619
Chromosome: 19
Canonical length: 493 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins, Transporters
Subcellular location: Vesicles

OverviewNCBI Gene

Predicted to be involved in G protein-coupled receptor signaling pathway and response to pheromone. Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

493 residues, UniProt reviewed canonical sequence.

>Q8NBT3|TMEM145
     1  MEPLRAPALR RLLPPLLLLL LSLPPRARAK YVRGNLSSKE DWVFLTRFCF LSDYGRLDFR
    61  FRYPEAKCCQ NILLYFDDPS QWPAVYKAGD KDCLAKESVI RPENNQVINL TTQYAWSGCQ
   121  VVSEEGTRYL SCSSGRSFRS GDGLQLEYEM VLTNGKSFWT RHFSADEFGI LETDVTFLLI
   181  FILIFFLSCY FGYLLKGRQL LHTTYKMFMA AAGVEVLSLL FFCIYWGQYA TDGIGNESVK
   241  ILAKLLFSSS FLIFLLMLIL LGKGFTVTRG RISHAGSVKL SVYMTLYTLT HVVLLIYEAE
   301  FFDPGQVLYT YESPAGYGLI GLQVAAYVWF CYAVLVSLRH FPEKQPFYVP FFAAYTLWFF
   361  AVPVMALIAN FGIPKWAREK IVNGIQLGIH LYAHGVFLIM TRPSAANKNF PYHVRTSQIA
   421  SAGVPGPGGS QSADKAFPQH VYGNVTFISD SVPNFTELFS IPPPATSPLP RAAPDSGLPL
   481  FRDLRPPGPL RDL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TMEM145 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 8
Mean surface accessibility (rSASA): 0.32
Highest tissue expression: 237 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 237 nTPM
cerebral cortex: 39 nTPM
hypothalamus: 27 nTPM
retina: 27 nTPM
basal ganglia: 22 nTPM
pituitary gland: 22 nTPM

Single-cell type

retinal amacrine cells: 82 nCPM
retinal ganglion cells: 58 nCPM
retinal horizontal cells: 52 nCPM
brain inhibitory neurons: 51 nCPM
brain excitatory neurons: 48 nCPM
retinal bipolar cells: 45 nCPM

Immune cell

neutrophil: 14 nTPM
basophil: 5 nTPM
naive B-cell: 1.2 nTPM
memory B-cell: 1.1 nTPM
total PBMC: 1.1 nTPM
eosinophil: 0.9 nTPM

Brain region

cerebellum: 154 nTPM
cerebral cortex: 90 nTPM
white matter: 56 nTPM
midbrain: 55 nTPM
thalamus: 54 nTPM
pons: 51 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.81
gnomAD pLI: 0
gnomAD missense Z: 0.85
DepMap mean gene effect: 0.12
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TMEM145 as an antibody target. Whether an autoantibody or antibody against TMEM145 could matter depends on whether native TMEM145 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TMEM145 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TMEM145 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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