Seroatlas · Human Serome Atlas

TMEM144

Transmembrane protein 144

Also known as: FLJ11155, TM144_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q7Z5S9
Gene: TMEM144
Ensembl: ENSG00000164124
Chromosome: 4
Canonical length: 345 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins, Transporters
Subcellular location: Mitochondria

OverviewNCBI Gene

Predicted to enable carbohydrate transmembrane transporter activity. Predicted to be involved in carbohydrate transmembrane transport. Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

345 residues, UniProt reviewed canonical sequence.

>Q7Z5S9|TMEM144
     1  MSNNGADLTF GYISCFVAIL LFGSNFVPLK KFDTGDGMFL QWVLCAAIWL VALVVNLILH
    61  CPKFWPFAML GGCIWATGNI AVVPIIKTIG LGLGILIWGS FNALTGWASS RFGWFGLDAE
   121  EVSNPLLNYI GAGLSVVSAF IFLFIKSEIP NNTCSMDTTP LITEHVINTT QDPCSWVDKL
   181  STVHHRIVGC SLAVISGVLY GSTFVPIIYI KDHSKRNDSI YAGASQYDLD YVFAHFSGIF
   241  LTSTVYFLAY CIAMKNSPKL YPEAVLPGFL SGVLWAIATC CWFIANHSLS AVVSFPIITA
   301  GPGFIAAMWG IFMFKEIKGL QNYLLMILAF CIILTGALCT AFSKI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TMEM144 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 10
Mean surface accessibility (rSASA): 0.26
Highest tissue expression: 219 nTPM

Expression across tissuesHPA

Tissue

spinal cord: 219 nTPM
midbrain: 105 nTPM
hippocampal formation: 82 nTPM
basal ganglia: 72 nTPM
cerebral cortex: 70 nTPM
amygdala: 50 nTPM

Single-cell type

oligodendrocytes: 1,570 nCPM
early spermatids: 286 nCPM
bergmann glia: 227 nCPM
adrenal cortex cells: 191 nCPM
astrocytes: 135 nCPM
late primary spermatocytes: 117 nCPM

Immune cell

plasmacytoid DC: 2.2 nTPM
myeloid DC: 2.1 nTPM
classical monocyte: 1.4 nTPM
intermediate monocyte: 0.6 nTPM
non-classical monocyte: 0.3 nTPM
total PBMC: 0.3 nTPM

Brain region

white matter: 847 nTPM
basal ganglia: 486 nTPM
medulla oblongata: 434 nTPM
cerebellum: 348 nTPM
thalamus: 344 nTPM
midbrain: 334 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.36
gnomAD pLI: 0
gnomAD missense Z: -0.1
DepMap mean gene effect: 0.06
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

carbohydrate transmembrane transporter activity

Cellular components

membrane

Protein domainsUniProt · Pfam · InterPro

Multidrug transporter EmrE superfamily
Sugar transport protein
TMEM144
Transmembrane family, TMEM144 of transporters

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TMEM144 as an antibody target. Whether an autoantibody or antibody against TMEM144 could matter depends on whether native TMEM144 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TMEM144 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TMEM144 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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