Seroatlas · Human Serome Atlas

TMEM143

Transmembrane protein 143

Also known as: FLJ10922, TM143_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96AN5
Gene: TMEM143
Ensembl: ENSG00000161558
Chromosome: 19
Canonical length: 459 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Nucleoli fibrillar center

OverviewNCBI Gene

Predicted to act upstream of or within hematopoietic progenitor cell differentiation. Located in mitochondrion. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

459 residues, UniProt reviewed canonical sequence.

>Q96AN5|TMEM143
     1  MTVELWLRLR GKGLAMLHVT RGVWGSRVRV WPLLPALLGP PRALSSLAAK MGEYRKMWNP
    61  REPRDWAQQY RERFIPFSKE QLLRLLIQEF HSSPAEKAAL EAFSAHVDFC TLFHYHQILA
   121  RLQALYDPIN PDRETLDQPS LTDPQRLSNE QEVLRALEPL LAQANFSPLS EDTLAYALVV
   181  HHPQDEVQVT VNLDQYVYIH FWALGQRVGQ MPLKSSVGSR RGFFTKLPPA ERRYFKRVVL
   241  AARTKRGHLV LKSFKDTPLE GLEQLLPELK VRTPTLQRAL LNLMLVVSGV AIFVNVGMVV
   301  LTDLKVATSL LLLLFAIFMG LRASKMFGQR RSAQALELAH MLYYRSTSNN SELLSALALR
   361  AQDEHTKEAL LAHSFLARRP GGTQGSPEET SRWLRSEVEN WLLAKSGCEV TFNGTRALAH
   421  LQALTPSMGL YPPPGFPKLD PVAPITSEPP QATPSSNIS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TMEM143 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.36
Highest tissue expression: 89 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 89 nTPM
tongue: 57 nTPM
heart muscle: 42 nTPM
liver: 17 nTPM
kidney: 11 nTPM
adrenal gland: 8.7 nTPM

Single-cell type

myonuclei: 51 nCPM
proximal tubule cells: 28 nCPM
distal convoluted tubule cells: 27 nCPM
renal connecting tubule cells: 24 nCPM
paneth cells: 23 nCPM
oocytes: 23 nCPM

Immune cell

NK-cell: 3.5 nTPM
MAIT T-cell: 2.7 nTPM
naive CD4 T-cell: 2.6 nTPM
gdT-cell: 2.2 nTPM
memory B-cell: 2.1 nTPM
memory CD8 T-cell: 2.1 nTPM

Brain region

cerebral cortex: 8.7 nTPM
basal ganglia: 7.5 nTPM
thalamus: 7.2 nTPM
white matter: 7.2 nTPM
pons: 6.9 nTPM
medulla oblongata: 6.7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.43
gnomAD pLI: 0
gnomAD missense Z: 0.21
DepMap mean gene effect: -0.06
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

Protein of unknown function DUF3754
Protein of unknown function (DUF3754)

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TMEM143 as an antibody target. Whether an autoantibody or antibody against TMEM143 could matter depends on whether native TMEM143 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TMEM143 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TMEM143 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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