Seroatlas · Human Serome Atlas

TMEM141

Transmembrane protein 141

Also known as: MGC14141, TM141_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q96I45
Gene
TMEM141
Ensembl
ENSG00000244187
Chromosome
9
Canonical length
108 aa
Protein class
Predicted membrane proteins
Subcellular location
Cell Junctions,Mitochondria

OverviewNCBI Gene

Located in mitochondrion. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

108 residues, UniProt reviewed canonical sequence.

>Q96I45|TMEM141
     1  MVNLGLSRVD DAVAAKHPGL GEYAACQSHA FMKGVFTFVT GTGMAFGLQM FIQRKFPYPL
    61  QWSLLVAVVA GSVVSYGVTR VESEKCNNLW LFLETGQLPK DRSTDQRS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TMEM141 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
2
Mean surface accessibility (rSASA)
0.51
Highest tissue expression
118 nTPM

Expression across tissuesHPA

Tissue

  • kidney: 118 nTPM
  • colon: 113 nTPM
  • rectum: 105 nTPM
  • liver: 103 nTPM
  • prostate: 100 nTPM
  • esophagus: 88 nTPM

Single-cell type

  • parietal cells: 209 nCPM
  • colonocytes: 82 nCPM
  • gastric chief cells: 56 nCPM
  • goblet cells: 52 nCPM
  • late spermatids: 49 nCPM
  • enteric transient amplifying cells: 44 nCPM

Immune cell

  • plasmacytoid DC: 91 nTPM
  • intermediate monocyte: 44 nTPM
  • non-classical monocyte: 38 nTPM
  • NK-cell: 30 nTPM
  • classical monocyte: 30 nTPM
  • total PBMC: 29 nTPM

Brain region

  • pons: 38 nTPM
  • cerebellum: 37 nTPM
  • white matter: 37 nTPM
  • medulla oblongata: 34 nTPM
  • hypothalamus: 32 nTPM
  • thalamus: 32 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.55
gnomAD pLI
0
gnomAD missense Z
-0.19
DepMap mean gene effect
-0.1
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Transmembrane protein 141
  • Tmem141 superfamily
  • TMEM141 protein family

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TMEM141 as an antibody target. Whether an autoantibody or antibody against TMEM141 could matter depends on whether native TMEM141 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TMEM141 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TMEM141 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TMEM141. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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